Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort
Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort
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DOI：
10.1016/j.jdiacomp.2017.09.010
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发表时间：
2018-01-01
影响因子：
3
通讯作者：
Thomsen, Reimar Wernich
中科院分区：
文献类型：
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作者：
Gedebjerg, Anne;Almdal, Thomas Peter;Thomsen, Reimar Wernich
目标：检查2型糖尿病（T2 D）诊断时微血管和大血管并发症的患病率及其相关临床特征。方法：我们检查了6958名新诊断的T2 D患者的并发症患病率及其相关临床特征，这些患者入组了丹麦前瞻性战略研究中心2010-2016年期间的T2 D队列。我们计算年龄和性别调整的患病率比（aPR）的并发症使用对数二项和Poisson regression.Results：在总的，35%（n = 2456）T2 D患者有糖尿病并发症的诊断; 12%（n = 828）有微血管并发症，17%（n = 1186）大血管并发症，6%（n = 442）有两者。HbA 1c水平与微血管并发症相关[HbA 1c 7%-8%; aPR：135，95%置信区间（CI）：1.12-1.62]，但与大血管并发症无关[aPR：0.91，95% CI：0.76-1.08]。高C肽800 pmol/L与大血管[aPR 1.34，95% CI：1.00-1.80]相关，但与微血管[aPR 0.97，95% CI：0.71-1.33]并发症无关。大血管并发症与男性、年龄> 50岁、肥胖、高脂血症、低HDL胆固醇、吸烟、CRP水平升高和抗高血压治疗相关。微血管并发症与高血压，高血脂症，并没有降脂therapy.Conclusions：三分之一的T2 D患者有糖尿病并发症的诊断时间。我们的研究结果表明，微血管和大血管并发症背后的不同病理生理机制。(C)2017爱思唯尔公司All rights reserved.
Aims: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.Methods: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log binomial and Poisson regression.Results: In total, 35% (n = 2456) T2D patients had diabetic complications around diagnosis; 12% (n = 828) had microvascular complications, 17% (n = 1186) macrovascular complications, and 6% (n = 442) had both. HbA1c levels of were associated with microvascular complications [HbA1c 7%-8%; aPR: 135, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide 800 pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age > 50 years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.Conclusions: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications. (C) 2017 Elsevier Inc. All rights reserved.