DNA methylation pathways and their crosstalk with histone methylation.
DNA methylation pathways and their crosstalk with histone methylation.
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DOI：
10.1038/nrm4043
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Patel DJ
中科院分区：
文献类型：
--
作者：
Du J;Johnson LM;Jacobsen SE;Patel DJ
DNA甲基化和组蛋白3在Lys 9（H3K9）的甲基化与从真菌到人类的真核生物中的基因沉默高度相关。这两种表观遗传标记都需要在基因组的特定区域建立，然后通过细胞分裂维持在这些位点。特异性识别甲基化DNA和甲基化组蛋白的蛋白质结构域是将催化这些标记的酶靶向到适当基因组位点的关键。遗传、基因组、结构和生化数据揭示了这两种表观遗传标记之间的联系，这些结构域介导了大部分串扰。
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.