Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines:: I.: Assessment of 'resistance' versus 'susceptibility' to S-japonicum infection
Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines:: I.: Assessment of 'resistance' versus 'susceptibility' to S-japonicum infection
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DOI：
10.1016/s0001-706x(02)00176-6
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发表时间：
2002-11-01
期刊：
影响因子：
2.7
通讯作者：
Olveda, RM
中科院分区：
文献类型：
--
作者：
Acosta, LP;Aligui, GDL;Olveda, RM
本研究描述了155个人生活在一个流行的村庄Macanip，莱特，菲律宾血吸虫感染的“耐药”或“易感”使用现有的暴露，感染和再感染的数据收集3年的水接触（WC）的研究分类。流行病学参数，包括年龄，性别和感染强度有关观察到的再感染模式也进行了说明。这种分类被用于随后的免疫学研究中，在两篇随附的论文中描述，以确定由确定的候选疫苗分子诱导的抵抗个体中的保护性免疫机制。山茱萸这项研究表明，最容易迅速再次感染的是5-14岁年龄组的儿童。15-19岁年龄组的发病率下降，以及从该年龄组和更大年龄组（15岁以上）开始的感染强度下降，表明免疫力的发展。控制其他变量的影响，多变量分析显示性别的显着关联，在女性更有可能是耐药。这意味着除了获得性免疫外，一些年龄依赖性宿主因素也可能在该人群日本血吸虫病再感染模式的总体变化中发挥重要作用。皇冠版权所有（C）2002出版的爱思唯尔科学B. V.保留所有权利。
This study describes the categorical classification of 155 individuals living in an endemic village in Macanip, Leyte, Philippines as 'resistant' or 'susceptible' to Schistosoma japonicum infection using available exposure, infection and reinfection data collected from a 3-year water contact (WC) study. Epidemiological parameters including age, sex, and infection intensities in relation to observed reinfection patterns are also described. This classification was used in subsequent immunological studies described in two accompanying papers to identify protective immune mechanisms among resistant individuals induced by defined candidate vaccine molecules for S. japonicum. The study suggests that individuals who were most vulnerable to rapid reinfection were children belonging to the 5-14 age group. A drop in incidence at age group 15-19 and decreased intensity of infection starting at this age group and older (15+) suggests development of immunity. Controlling for the effect of the other variables, a multivariate analysis showed significant association for sex, in that females were more likely to be resistant. This implies that other than acquired immunity to infection, some age-dependent host factors may also play an important role in the overall changes of reinfection patterns seen in schistosomiasis japonica in this population. Crown Copyright (C) 2002 Published by Elsevier Science B.V. All rights reserved.