Effect of temperature on myocardial infarction in swine
Effect of temperature on myocardial infarction in swine
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DOI：
10.1152/ajpheart.1996.270.4.h1189
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发表时间：
1996-04-01
影响因子：
4.8
通讯作者：
Bache, RJ
中科院分区：
文献类型：
--
作者：
Duncker, DJ;Klassen, CL;Bache, RJ
正常体温范围内的体核温度会改变兔的梗死面积。此外，温度可能会调节冠状动脉闭塞期间腺苷的保护作用。我们研究了正常体温范围（35 - 39℃）内的体核温度对开胸猪（n = 10）冠状动脉闭塞45分钟所产生的心肌梗死面积的影响，并且我们确定了用8 - 苯基茶碱和腺苷脱氨酶阻断腺苷是否会增加正常体温范围内的梗死面积（n = 9）。再灌注4小时后，用伊文思蓝染料和氯化三苯基四氮唑测定危险区域和梗死面积。梗死面积与温度密切相关（r² = 0.71，P = 0.0001），以至于在35℃时没有发生梗死，并且温度每升高1℃，危险区域的20%会发生梗死。相比之下，低水平的侧支血流（0.03 ± 0.01 ml·min⁻¹·g⁻¹）和心率 - 血压乘积都与梗死面积无关。在正常体温范围内，腺苷阻断对梗死面积没有影响。这些数据表明温度可以对梗死面积产生深远影响，但未能证明在正常体温下内源性腺苷的保护作用。我们的研究结果强调在研究旨在减少梗死面积的干预措施时，需要严格控制体核温度。
Body core temperature in the normothermic range alters infarct size in rabbits. Moreover, temperature may modulate the protection by adenosine during a coronary artery occlusion. We investigated the effect of core temperature within the normothermic range (35-39 degrees C) on myocardial infarct size produced by a 45-min coronary occlusion in open-chest swine (n = 10), and we determined whether adenosine blockade with 8-phenyltheophylline and adenosine deaminase increased infarct size in the normothermic range (n = 9). After 4 h of reperfusion the area at risk and infarct size were determined with Evans blue dye and triphenyltetrazolium chloride. Infarct size strongly correlated with temperature (r(2) = 0.71, P = 0.0001) so that at 35 degrees C no infarction occurred and with each 1 degrees C increase in temperature 20% of the area at risk became infarcted. In contrast, neither the low levels of collateral flow (0.03 +/- 0.01 ml . min(-1) . g(-1)) nor the rate-pressure product correlated with infarct size. In the normothermic range, adenosine blockade had no effect on infarct size. The data demonstrate that temperature can exert a profound effect on infarct size but fail to demonstrate a protective effect of endogenous adenosine at normothermic temperatures. Our findings emphasize the need for stringent control of core temperature during investigation of interventions aimed at reducing infarct size.