THE EYE IN BONE-MARROW TRANSPLANTATION .1. CLINICAL-STUDY
THE EYE IN BONE-MARROW TRANSPLANTATION .1. CLINICAL-STUDY
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DOI：
10.1001/archopht.1983.01040010580010
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
TUTSCHKA, PJ
中科院分区：
文献类型：
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作者：
HIRST, LW;JABS, DA;TUTSCHKA, PJ
对45例接受骨髓移植[治疗再生障碍性贫血和淋巴造血系统恶性肿瘤]的患者进行了前瞻性研究，包括全面的眼部检查和移植前和移植后结膜活检。主要发现是45名患者中有20名出现严重的干燥性角结膜炎综合征，并且与急性移植物抗病毒的发生密切相关。-宿主病（GVHD）。急性GVHD暴发期发生急性假膜性结膜炎6例。另外10例患者对骨髓移植进行了回顾性评估，并证实了这些临床结果。
A prospective study of 45 patients undergoing bone marrow transplantation [for the treatment of aplastic anemia and lymphohematopoietic malignant neoplasms] included full ocular examination and pretransplant and posttransplant conjunctival biopsies. The major finding was the development of a severe keratoconjunctivitis sicca syndrome that developed in 20 of the 45 patients and closely correlated with the occurrence of acute graft-vs.-host disease (GVHD). An acute pseudomembranous conjunctivitis in the fulminant stage of acute GVHD developed in 6 patients. A further 10 patients made up a retrospective assessment of bone marrow transplantation and confirmed these clinical findings.