mTOR and lysosome regulation.
mTOR and lysosome regulation.
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DOI：
10.12703/p6-52
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Puertollano R
中科院分区：
文献类型：
--
作者：
Puertollano R
溶酶体是关键的细胞器，其通过降解细胞外和细胞内物质而在催化剂中起关键作用。因此，非常有趣的是，mTORC 1（雷帕霉素复合物1的机械靶标），合成代谢过程的主要启动子，以其活性形式定位于溶酶体表面。近年来，许多令人兴奋的观察已经揭示了mTORC 1活性和溶酶体功能之间的严格调节的串扰。这些发现强调了调节细胞能量代谢的复杂调控网络。
Lysosomes are key cellular organelles that play a crucial role in catabolism by degrading extracellular and intracellular material. It is, therefore, very intriguing that mTORC1 (mechanistic target of rapamycin complex 1), a major promoter of anabolic processes, localizes in its active form to the surface of lysosomes. In recent years, many exciting observations have revealed a tightly regulated crosstalk between mTORC1 activity and lysosomal function. These findings highlight the complex regulatory network that modulates energy metabolism in cells.