Numerical Simulation of Bone Remodeling Coupling the Damage Repair Process in Human Proximal Femur
Numerical Simulation of Bone Remodeling Coupling the Damage Repair Process in Human Proximal Femur
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DOI：
10.32604/cmes.2020.012407
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
C. Qu;H. Yuan
中科院分区：
文献类型：
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作者：
C. Qu;H. Yuan
：骨组织在生理负荷的长期作用下，以及年龄、疾病等因素的影响下产生微损伤。骨重塑可以修复微损伤，否则这种损伤会破坏骨质量，甚至导致骨折。本文将损伤变量引入重构算法。新的重构算法包含一个二次项，可以模拟大量加载循环后骨密度的减少。将该模型与三维有限元法（FEM）结合应用于股骨近端重构。结果表明，疲劳损伤的初始积累导致骨密度增加，但当损伤达到一定程度时，骨密度迅速下降，直至股骨失效。随着损伤的积累，骨重塑与疲劳损伤相结合以维持骨的功能。当损伤积累达到一定程度时，骨重塑不能及时修复累积的疲劳损伤，持续的循环加载明显削弱了骨的承载能力。新的数学模型不仅可以预测疲劳寿命，而且有助于进一步了解损伤修复与损伤积累之间的折衷关系，对临床骨病的预防和治疗具有重要意义。
: Microdamage is produced in bone tissue under the long-term effects of physiological loading, as well as age, disease and other factors. Bone remodeling can repair microdamage, otherwise this damage will undermine bone quality and even lead to fractures. In this paper, the damage variable was introduced into the remodeling algorithm.The new remodeling algorithm contains a quadratic term that can simulate reduction in bone density after large numbers of loading cycles. The model was applied in conjunction with the 3D finite element method (FEM) to the remodeling of the proximal femur. The results showed that the initial accumulation of fatigue damage led to an increase in density but when the damage reached a certain level, the bone density decreased rapidly until the femur failed. With the accumulation of damage, bone remodeling was coupled with fatigue damage to maintain the function of bone. When the accumulation of damage reached a certain level, bone remodeling failed to repair the accumulated fatigue damage in time, and continued cyclic loading significantly weakened the loadbearing capacity of the bone. The new mathematical model not only predicts fatigue life, but also helps to further understand the compromise between damage repair and damage accumulation, which is of great significance for the prevention and treatment of clinical bone diseases.