Population genetics analysis of 38 STR loci in the She population from Fujian Province of China
Population genetics analysis of 38 STR loci in the She population from Fujian Province of China
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DOI：
10.1016/j.legalmed.2014.05.008
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发表时间：
2014-09-01
期刊：
影响因子：
1.5
通讯作者：
Zhang, Lin
中科院分区：
文献类型：
--
作者：
Yuan, Li;Ou, Yuan;Zhang, Lin
在福建省畲族154例无亲缘关系个体中，共检测到38个常染色体短串联重复基因位点（D5S818、D21S11、D7S820、CSF1P0、D2S1338、D3S1358、vWA、D8S1179、D16S539、Penta E、TPDX、TH01、D19S433、D18S51、FGA、D6S1043、D13S317、D125391、D6S474、D12ATA63、D22S1045、D10S1248、d11677、D11S4463、D1S1627、D3S4529、D4S2408、D17S1301、D1GATA113、D18S853、D20S482、D14S1434、D9S1122、D2S1776、D10S1435、D5S2500）。结果表明，这38个STR基因座具有较高或中等的鉴别能力和排除概率。检验了各位点的Hardy-Weinberg平衡和位点间的连锁不平衡。估计了畲族与其他中国人群的遗传距离（即f1）。综上所述，这些基因座对该地区畲族人群的法医学应用，特别是亲属关系分析具有重要意义。2014爱思唯尔爱尔兰有限公司版权所有。
A total of 38 autosomal Short Tandem Repeat (STR) loci (i.e., D5S818, D21S11, D7S820, CSF1P0, D2S1338, D3S1358, vWA, D8S1179, D16S539, Penta E, TPDX, TH01, D19S433, D18S51, FGA, D6S1043, D13S317, D125391, D6S474, D12ATA63, D22S1045, D10S1248, D1S1677, D11S4463, D1S1627, D3S4529, D2S441, D6S1017, D4S2408, D17S1301, D1GATA113, D18S853, D20S482, D14S1434, D9S1122, D2S1776, D10S1435, D5S2500) were analyzed in the She population from Fujian Province of China with 154 unrelated individuals. The results show these 38 STR loci have high or medium power of discrimination and probabilities of exclusion. The Hardy-Weinberg Equilibrium of each locus and Linkage Disequilibrium among these loci were tested. The genetic distances (i.e., Fst) among the She population and other Chinese populations were estimated. In conclusion, these loci are very useful for forensic applications, especially kinship analysis, in the She population of this region. (C) 2014 Elsevier Ireland Ltd. All rights reserved.