Structural Design of Oleogel‐Hydrogel Bigels for Co‐Delivery of Curcumin and Epigallocatechin Gallate with Synergistic Stability and Bioactivity
Structural Design of Oleogel‐Hydrogel Bigels for Co‐Delivery of Curcumin and Epigallocatechin Gallate with Synergistic Stability and Bioactivity
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DOI：
10.1002/admt.202202185
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发表时间：
2023-06
影响因子：
6.8
通讯作者：
Jingyi Yang;Yu Fu;Hongxia Zheng;Y. Jia;Yanxiang Gao;Shutao Yin;Like Mao
中科院分区：
文献类型：
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作者：
Jingyi Yang;Yu Fu;Hongxia Zheng;Y. Jia;Yanxiang Gao;Shutao Yin;Like Mao
Bigels是含有水凝胶和油凝胶结构的新型双相系统，其被设计为递送多种生物活性物质以实现协同活性。目前的研究开发基于角叉菜胶水凝胶和单甘油酯（GMS）油凝胶的bigels。结果表明，两种表面活性剂（吐温20和聚甘油聚蓖麻油酸酯）可以很好地修饰bigels的微观结构，进而影响bigels的微观结构。当姜黄素和表没食子儿茶素没食子酸酯（表没食子儿茶素没食子酸酯）同时输送时，生物活性物质会协同作用，减缓热降解。模拟消化试验表明，双凝胶结构能延缓两种生物活性物质在人工唾液和模拟胃液（SGF）中的释放，而在模拟肠液（SIF）中能快速释放。DPPH和ABTS试验表明，含有EGCG和姜黄素的消化Tween 20 bigels具有协同抗氧化活性。在人结肠腺癌HCT 116中评价抗癌活性，并且两种生物活性物质协同作用以降低细胞活力。从吐温20双凝胶中释放的生物活性物质比从聚甘油聚蓖麻油酸酯双凝胶中释放的生物活性物质具有更高的细胞毒性。结果表明，bigels的简单结构设计具有实现共递送生物活性物质的协同稳定性和生物活性的潜力，这对于功能性药物、化妆品和食品的开发具有意义。
Bigels are novel biphasic systems containing hydrogel and oleogel structures, which are designed to deliver multiple bioactives for synergistic activity. The current study develops bigels based on a carrageenan hydrogel and a monoglyceride (GMS) oleogel. Results show that the microstructures of bigels are facilely modified by two surface active ingredients (Tween 20 and polyglycerol polyricinoleate), which then influence the microstructures of the bigels. When curcumin and epigallocatechin gallate (EGCG) are delivered simultaneously, the bioactives work synergistically to slow thermal degradation. Simulated digestion tests indicate that the bigel structures can delay the release of the two bioactives in artificial saliva and simulated gastric fluid (SGF), and allow fast release in simulated intestinal fluid (SIF). DPPH and ABTS tests show the digested Tween 20 bigels containing EGCG and curcumin present synergistic antioxidant activity. Anticancer activity is evaluated in human colon adenocarcinoma HCT116, and the two bioactives work cooperatively to lower cell viability. The bioactives released from Tween 20 bigels have higher cytotoxicity than those from polyglycerol polyricinoleate bigels. The results reveal that facile structural design of bigels has the potential to achieve synergistic stability and bioactivity of co‐delivered bioactives, which is meaningful for the development of functional pharmaceutical, cosmetic, and food products.