Investigation into the cross-correlation of salivary cortisol and alpha-amylase responses to psychological stress
Investigation into the cross-correlation of salivary cortisol and alpha-amylase responses to psychological stress
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DOI：
10.1016/j.psyneuen.2011.02.018
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发表时间：
2011-10-01
影响因子：
3.7
通讯作者：
Pruessner, Jens C.
中科院分区：
文献类型：
--
作者：
Engert, Veronika;Vogel, Susanne;Pruessner, Jens C.
压力是一个多层面的结构。为了准确地表示压力生理学，应评估跨多个压力相关系统的多个压力测量。然而，考虑到不同的系统是不同的时间进程的基础，关联可能会被掩盖。唾液皮质醇和α-淀粉酶（sAA）分别是交感神经系统（SNS）和下丘脑垂体肾上腺（HPA）轴的可靠生物应激标志物。研究sAA和皮质醇水平之间的联系对压力的反应产生了不一致的结果。在这里，我们调查是否协方差的压力引起的sAA和皮质醇释放是依赖于不同的时间动态的两个压力标记。在两项独立的研究中，共有50名男性参与者暴露于高频率（2分钟间隔）唾液采样的心理实验室应激源。同步的时间序列的sAA和皮质醇的措施之前，期间和之后的应激诱导。交叉相关分析被应用到测试的关联sAA和皮质醇水平在各个阶段相对于发病的压力。在这两项研究中，发现sAA和皮质醇措施滞后对之间的正相关和负相关。在皮质醇释放前13.5分钟，sAA的相关性最强（r = 0.27，p <0.001）。在较小的效应量下，皮质醇也显著先于sAA 13.5分钟（r =-0.16，p <0.001）。我们认为，sAA和皮质醇的压力反应是可靠的关联在不同的时间滞后在整个紧张的情况下。作为HPA轴和SNS之间可能的连接点，可能是sAA-皮质醇协会的基础，我们讨论了下丘脑CRF神经元参与交感神经调节。(C)2011爱思唯尔有限公司保留所有权利。
Stress is a multidimensional construct. To accurately represent stress physiology, multiple stress measures across multiple stress-related systems should be assessed. However, associations may be masked given that different systems underlie different time courses. Salivary cortisol and alpha-amylase (sAA) are reliable biological stress markers of the sympathetic nervous system (SNS) and the hypothalamus pituitary adrenal (HPA) axis, respectively. Studies examining the link between sAA and cortisol levels in response to stress have produced inconsistent results. Here, we investigated whether the covariance of stress-induced sAA and cortisol release is dependent on the distinct temporal dynamics of the two stress markers. A total of 50 male participants were exposed to a psychological laboratory stressor with high frequency (2-min interval) saliva sampling in two independent studies. Synchronized time series of sAA and cortisol measures before, during and after stress induction were obtained. Cross-correlation analysis was applied to test for the association of sAA and cortisol levels at various stages relative to the onset of the stressor. Positive and negative cross-correlations between lagged pairs of sAA and cortisol measures were found in both studies. The strongest correlation was found for sAA preceding cortisol release by 13.5 min (r = .27, p < .001). With a smaller effect size cortisol also significantly preceded sAA by 13.5 min (r = -.16, p < .001). We suggest that sAA and cortisol stress responses are reliably associated at various time lags throughout a stressful situation. As a possible connection site between HPA axis and SNS that may underlie sAA-cortisol associations, we discuss CRF neurons of the hypothalamus involved in sympathetic regulation. (C) 2011 Elsevier Ltd. All rights reserved.