Walking capacity of Japanese patients with colorectal cancer relates to early postoperative health-related quality of life: a multi-center cohort study
Walking capacity of Japanese patients with colorectal cancer relates to early postoperative health-related quality of life: a multi-center cohort study
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日本结直肠癌患者的步行能力与术后早期健康相关生活质量相关：一项多中心队列研究
DOI：
10.1080/09593985.2023.2204481
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发表时间：
2023
影响因子：
2
通讯作者：
Kakuda Wataru
中科院分区：
文献类型：
--
作者：
Hara Tsuyoshi;Kogure Eisuke;Iijima Shinno;Fukawa Yasuhisa;Kubo Akira;Kakuda Wataru
目的探讨手术治疗对日本结直肠癌患者健康相关生活质量（HRQOL）的影响。方法本研究纳入106例日本结直肠癌患者（69例男性，平均年龄：62.6±12.4岁，年龄范围= 30-85岁）。HRQOL是在手术前1 - 2天（基线）和术后4周使用36项健康调查简表第2版进行评估的。调查临床特征、社会特征和基线时的HRQOL。结果术后4周身体功能、生理角色、身体疼痛和社交功能较基线显著下降，而心理健康显著改善。身体功能和总体健康感知与术后4周的6分钟步行测试（6MWT）和基线HRQOL评分之间的关系尤为密切。临床相关改善的6MWT截断值为身体功能552.5米（曲线下面积[AUC] = 0.780, 95%可信区间[CI] = 0.692-0.867），一般健康感知480.3米（AUC = 0.721, 95% CI = 0.626-0.817）。结论CRC患者术后行走能力的提高有改善术后HRQOL的潜力，但可能需要出院后的随访干预，如肢体康复等。研究结果为改善日本结直肠癌患者的HRQOL提供了一条潜在途径。
PurposeThis study investigated the impact of surgical treatment on the health-related quality of life (HRQOL) of Japanese patients with colorectal cancer (CRC).MethodsThis three-institution cohort study included 106 Japanese patients with CRC (69 men; mean age: 62.6 ± 12.4 years; age range = 30–85 years). HRQOL was evaluated using the Short-Form 36-Item Health Survey version 2 one to two days prior to surgery (baseline) and four weeks after surgery. Clinical characteristics, social characteristics, and HRQOL at baseline were investigated.ResultsPhysical functioning, role-physical, bodily pain, and social functioning decreased significantly at four weeks after surgery compared with baseline, whereas mental health significantly improved. Physical functioning and general health perception showed an especially strong relation with the six-minute walk test (6MWT) at four weeks after surgery and HRQOL scores at baseline. The cutoff value for the 6MWT for clinically relevant improvement was 552.5 meters for physical functioning (area under curve [AUC] = 0.780, 95% confidence interval [CI] = 0.692–0.867) and 480.3 meters for general health perception (AUC = 0.721, 95% CI = 0.626–0.817).ConclusionPatients with CRC could potentially improve their postoperative HRQOL by increasing their walking capacity post-surgery, and they may need follow-up interventions after discharge such as physical rehabilitation to do so. The results provide a potential pathway for improving HRQOL of Japanese patients with CRC.