Indirect Genetic Effects: A Cross-disciplinary Perspective on Empirical Studies
Indirect Genetic Effects: A Cross-disciplinary Perspective on Empirical Studies
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DOI：
10.1093/jhered/esab059
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发表时间：
2021-05-10
影响因子：
3.1
通讯作者：
Hughes, Kimberly A.
中科院分区：
文献类型：
--
作者：
Baud, Amelie;McPeek, Sarah;Hughes, Kimberly A.
当个体的表型受到同种遗传变异的影响时，就会发生间接遗传效应（IGE）。 IGE 的机会无处不在，而且当 IGE 存在时，它会对行为、进化、农业和生物医学遗传学产生深远的影响。尽管 IGE 很重要，但其实证研究却落后于理论的发展。在很大程度上，这种滞后可归因于这样一个事实：测量 IGE 并将其与个体自身基因型的直接遗传效应去卷积，会遇到许多潜在的陷阱。在本视角中，我们描述了所有学科的经验主义者在衡量和理解 IGE 时将遇到的当前挑战。我们还利用进化、农业和生物医学遗传学的想法和例子，描述了这些挑战的潜在解决方案，重点关注基因组、监测和表型技术的最新进展所提供的机遇。我们希望这种跨学科评估将推进了解生物学中同种相互作用的普遍影响的目标。
Indirect genetic effects (IGE) occur when an individual's phenotype is influenced by genetic variation in conspecifics. Opportunities for IGE are ubiquitous, and, when present, IGE have profound implications for behavioral, evolutionary, agricultural, and biomedical genetics. Despite their importance, the empirical study of IGE lags behind the development of theory. In large part, this lag can be attributed to the fact that measuring IGE, and deconvoluting them from the direct genetic effects of an individual's own genotype, is subject to many potential pitfalls. In this Perspective, we describe current challenges that empiricists across all disciplines will encounter in measuring and understanding IGE. Using ideas and examples spanning evolutionary, agricultural, and biomedical genetics, we also describe potential solutions to these challenges, focusing on opportunities provided by recent advances in genomic, monitoring, and phenotyping technologies. We hope that this cross-disciplinary assessment will advance the goal of understanding the pervasive effects of conspecific interactions in biology.