The function of adipocytes in the bone marrow stroma.
The function of adipocytes in the bone marrow stroma.
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发表时间：
1990-04
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通讯作者：
J. Gimble
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作者：
J. Gimble
骨髓基质的成纤维细胞和脂肪细胞提供循环血细胞成熟和增殖所需的细胞因子和细胞外基质蛋白。由于骨髓作为一种器官的复杂性，这些基质细胞的正常生理机制尚不清楚。特别是，脂肪细胞在骨髓中的作用仍然存在争议。克隆骨髓基质细胞系为淋巴造血微环境分析提供了体外模型。这些细胞可能具有多种分化途径，假设体外脂肪细胞、软骨细胞、肌细胞和骨细胞的表型。这些细胞系的特性和最近的体内实验为骨髓的正常生理提供了新的见解。
The fibroblasts and adipocytes of the bone marrow stroma provide the cytokines and extracellular matrix proteins required for the maturation and proliferation of the circulating blood cells. Due to the complexity of the bone marrow as an organ, the normal physiology of these stromal cells is not well understood. In particular, the role of adipocytes in the bone marrow remains controversial. Cloned bone marrow stromal cell lines provide an in vitro model for analysis of the lympho-hematopoietic microenvironment. These cells may be capable of multiple differentiation pathways, assuming the phenotype of adipocytes, chondrocytes, myocytes, and osteocytes in vitro. Characterization of these cell lines and recent in vivo experiments give new insight into the normal physiology of the bone marrow.