Intravoxel Incoherent Motion Imaging Study of Madecassoside in Improving Lipopolysaccharide‐Induced Cognitive Impairment in Rats
Intravoxel Incoherent Motion Imaging Study of Madecassoside in Improving Lipopolysaccharide‐Induced Cognitive Impairment in Rats
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DOI：
10.1002/jmri.27003
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发表时间：
2019-11
影响因子：
4.4
通讯作者：
Minjie Liang;Guangming Li;Xueqin Guan;Sisi Liu;Liguang Fang;Tianfu Li;Jun Dong;Quan Zhou
中科院分区：
文献类型：
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作者：
Minjie Liang;Guangming Li;Xueqin Guan;Sisi Liu;Liguang Fang;Tianfu Li;Jun Dong;Quan Zhou
中枢神经系统炎症与神经退行性疾病有关，被认为在导致认知障碍的病理生理级联反应中发挥了作用。Madecassoside(MA)已显示出治疗神经炎症的潜力。脂多糖可用于建立神经炎症所致认知功能障碍的动物模型。体素内非相干运动(IVIM)可潜在地提供扩散和灌注数据。
Central nervous system inflammation is associated with neurodegenerative diseases and is thought to play a part in the pathophysiological cascade leading to cognitive impairment. Madecassoside (MA) has shown potential for the treatment of neuroinflammation. Lipopolysaccharide (LPS) can be used to establish an animal model of cognitive dysfunction induced by neuroinflammation. Intravoxel incoherent motion (IVIM) may potentially provide diffusion and perfusion data.