T Cells in Celiac Disease.
T Cells in Celiac Disease.
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DOI：
10.4049/jimmunol.1601693
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发表时间：
2017-04-15
期刊：
影响因子：
--
通讯作者：
Sollid LM
中科院分区：
文献类型：
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作者：
Jabri B;Sollid LM
乳糜泻是一种人类T细胞介导的自身免疫样疾病，由遗传易感个体暴露于膳食麸质引起。本文将讨论如何针对外源性抗原的CD4 T细胞反应可以引起自身反应性B细胞反应，并参与许可的上皮内淋巴细胞杀死肠上皮细胞。此外，审查将检查上皮内细胞毒性T细胞介导的乳糜泻组织破坏的机制。
Celiac disease is a human T cell mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how a CD4 T cell responses directed against an exogenous antigen can cause an autoreactive B-cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, the review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.