Comprehensive brain analysis with automated high-resolution magnetization transfer measurements.
Comprehensive brain analysis with automated high-resolution magnetization transfer measurements.
复制标题
通过自动高分辨率磁化传递测量进行全面的大脑分析。
DOI：
10.1002/jmri.22835
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Edelman,RobertR
中科院分区：
文献类型：
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作者：
Wu,Ying;Du,Hongyan;Storey,Pippa;Glielmi,Christopher;Malone,Fiona;Sidharthan,Shawn;Ragin,Ann;Tofts,PaulS;Edelman,RobertR
PurposeTo提高的可靠性和空间分辨率的磁化传递比（MTR）测量询问皮质下的大脑区域与自动体积感兴趣（VOI）approach.Materials和MethodsA的3D磁化传递（MT）序列获得使用扫描-再扫描成像协议在9名健康志愿者。使用FreeSurfer生成MTR测量的VOI定义掩码，并与手动感兴趣区域（ROI）方法进行比较。(The使用琼脂凝胶体模在5个月内监测MTR的纵向稳定性。）组内相关系数（ICC），变异系数（CV），和仪器标准偏差（ISD）determined. ResultsCV范围从1.29%-2.64%（自动）与1.30%-3.40%（手动）。ISD范围为0.62-1.10 pu（自动）与0.68-1.67 pu（手动）。体模扫描的运行差异SD为1.70%。Bland-Altman方法表明自动VOI和手动ROI measurements.ConclusionThe自动VOI方法MTR测量产生了较高的ICC，较低的CV，和较低的ISDs相比，手动方法，支持该策略的实用性。这些结果表明，在海马和其他关键的皮层下区域获得可靠的MTR测量的可行性。J.磁共振Imaging 2012;309 - 317.© 2011 Wiley Periodicals，Inc.
PurposeTo enhance the reliability and spatial resolution of magnetization transfer ratio (MTR) measurements for interrogation of subcortical brain regions with an automated volume of interest (VOI) approach.Materials and MethodsA 3D magnetization transfer (MT) sequence was acquired using a scan‐rescan imaging protocol in nine healthy volunteers. VOI definition masks for the MTR measurements were generated using FreeSurfer and compared to a manual region of interest (ROI) approach. (The longitudinal stability of MTR was monitored using agar gel phantom over a 5‐month period.) Intraclass correlation coefficients (ICCs), coefficients of variation (CVs), and instrumental standard deviation (ISD) were determined.ResultsCVs ranged from 1.29%–2.64% (automated) vs. 1.30%–3.40% (manual). ISDs ranged from 0.62–1.10 pu (automated) vs. 0.68–1.67 pu (manual). The SD of the running difference was 1.70% for the phantom scans. The Bland–Altman method indicated interchangeability of the automated VOI and manual ROI measurements.ConclusionThe automated VOI approach for MTR measurement yielded higher ICCs, lower CVs, and lower ISDs compared to the manual method, supporting the utility of this strategy. These results demonstrate the feasibility of obtaining reliable MTR measurements in hippocampus and other critical subcortical regions. J. Magn. Reson. Imaging 2012;309‐317. © 2011 Wiley Periodicals, Inc.