Inhibition of food intake in obese subjects by peptide YY3-36
Inhibition of food intake in obese subjects by peptide YY3-36
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DOI：
10.1056/nejmoa030204
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发表时间：
2003-09-04
影响因子：
158.5
通讯作者：
Bloom, SR
中科院分区：
文献类型：
--
作者：
Batterham, RL;Cohen, MA;Bloom, SR
背景：肠激素片段肽YY 3 -36（PYY）在输注到正常体重的受试者中时降低食欲和食物摄入。与脂肪细胞激素瘦素一样，PYY通过调节下丘脑中的食欲回路来减少食物摄入。然而，在肥胖症中，存在对瘦素的作用的显著抵抗，这极大地限制了其治疗效果。我们调查了肥胖受试者是否也耐PYY的厌食作用。方法：我们比较了PYY输注对12个肥胖和12个瘦受试者的食欲和食物摄入量的影响，在一项双盲，安慰剂对照，交叉研究。结果：在注射PYY后2小时，肥胖者在自助午餐期间的热量摄入减少了30%（P
Background: The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces food intake by modulating appetite circuits in the hypothalamus. However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigated whether obese subjects were also resistant to the anorectic effects of PYY.Methods: We compared the effects of PYY infusion on appetite and food intake in 12 obese and 12 lean subjects in a double-blind, placebo-controlled, crossover study. The plasma levels of PYY, ghrelin, leptin, and insulin were also determined.Results: Caloric intake during a buffet lunch offered two hours after the infusion of PYY was decreased by 30 percent in the obese subjects (P