High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes
High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes
复制标题
DOI：
10.2337/dc07-1276
复制
发表时间：
2008-02-01
期刊：
影响因子：
16.2
通讯作者：
Witteman, Jacqueline C. M.
中科院分区：
文献类型：
--
作者：
Dehghan, Abbas;van Hoek, Mandy;Witteman, Jacqueline C. M.
目的：探讨血尿酸水平与2型糖尿病发病风险之间的关系。研究设计与方法：分析人群包括4536名基线时未患糖尿病的受试者。结果：与第一个四分位数相比，年龄和性别调整后的糖尿病风险比(95%CLS)分别为1.30(0.96-1.76)、1.63(1.21-2.19)和2.83(2.13-3.76)。在调整了BMI、腰围、收缩和舒张压以及高密度脂蛋白后，HRs分别降至1.08(0.78-1.49)、1.12(0.81-1.53)和1.68(1.22-2.30)。结论--这项以人群为基础的研究结果表明，血尿酸是糖尿病的一个强有力的独立危险因素。
OBJECTIVE - To investigate the association between serum uric acid level and risk of type 2 diabetes.RESEARCH DESIGN AND METHODS - The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes.RESULTS - The age- and sex-adjusted hazard ratios (HRs) (95% Cls) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively.CONCLUSIONS - The results of this population-based study suggest that Serum uric acid is a Strong and independent risk factor for diabetes.