HLA antigens in ulcerative colitis and primary sclerosing cholangitis
HLA antigens in ulcerative colitis and primary sclerosing cholangitis
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溃疡性结肠炎和原发性硬化性胆管炎中的 HLA 抗原
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
K. Höckerstedt
中科院分区：
文献类型：
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作者：
M. Leidenius;S. Koskimies;I. Kellokumpu;K. Höckerstedt
本研究的目的是了解HLA I类或II类区域的等位基因是否与溃疡性结肠炎的易感性相关，并显示原发性硬化性胆管炎与溃疡性结肠炎之间的HLA相关性是否存在差异或相似。采用标准淋巴细胞微细胞毒性试验研究了24例芬兰原发性硬化性胆管炎患者、77例溃疡性结肠炎患者和106例对照患者的HLA‐A、B、C和DR抗原。HLA‐B8（54%）和DR3（60%）与原发性硬化性胆管炎相关。HLA - DR1（46%）和DR6（20%）似乎在溃疡性结肠炎中比在对照组中更常见。与Cw7呈正相关在溃疡性结肠炎（25%）和原发性硬化性胆管炎（33%）中都很常见。我们的研究结果表明，溃疡性结肠炎在HLA - DR相关性方面比原发性硬化性胆管炎更具异质性。
The aims of this study were to find out whether the alleles of the HLA class I or II region are associated with susceptibility to ulcerative colitis, and to show whether there is a difference or similarity in HLA associations between primary sclerosing cholangitis and ulcerative colitis. HLA‐A, B, C and DR antigens were studied using the standard lymphocyte microcytotoxicity test in 24 Finnish patients with primary sclerosing cholangitis, 77 patients with ulcerative colitis, and 106 controls. HLA‐B8 (54%) and DR3 (60%) were associated with primary sclerosing cholangitis. HLA‐DR1 (46%) and DR6 (20%) seemed more common in ulcerative colitis than in controls. A positive association with Cw7 was common to both ulcerative colitis (25%) and primary sclerosing cholangitis (33%). Our results indicate that ulcerative colitis is more heterogeneous than primary sclerosing cholangitis in its HLA‐DR associations.
中性粒细胞胞浆抗体：原发性硬化性胆管炎和溃疡性结肠炎之间的联系。
影响因子：
29.4
作者：
Duerr,RH;Targan,SR;Landers,CJ;LaRusso,NF;Lindsay,KL;Wiesner,RH;Shanahan,F
通讯作者：
Shanahan,F
原发性硬化性胆管炎中的 HLA 抗原。
影响因子：
0.9
作者：
Noguchi,K;Kobayashi,M;Yagihashi,A;Yoshida,Y;Terasawa,K;Konno,A;Ichida,F;Venek,M;Iwatsuki,S;Starzl,TE
通讯作者：
Starzl,TE