Oral manifestations of HIV infection and their correlation with CD4 count.
Oral manifestations of HIV infection and their correlation with CD4 count.
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HIV 感染的口腔表现及其与 CD4 计数的相关性。
DOI：
10.2334/josnusd.53.203
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发表时间：
2011
影响因子：
1.9
通讯作者：
V. Hazarey
中科院分区：
文献类型：
--
作者：
Ashish S. Bodhade;S. Ganvir;V. Hazarey
人类免疫缺陷病毒（HIV）相关的口腔病变可作为免疫状态的标志。本横断面研究旨在确定HIV感染者的口腔表现及其与分化抗原4（CD 4）计数降低的相关性。研究人群包括已知的HIV阳性患者。获得了399例HIV阳性患者的详细病史，并进行了一般检查。口腔病变的诊断是根据EEC Clearinghouse，1993的假定标准进行的。对369例患者进行了CD 4计数测定，并与口腔表现进行了相关性分析。口腔病变的患病率为76.70%（n = 306）。口腔念珠菌病（157例（39.3%））是最常见的与HIV感染相关的口腔病变。在各种形式的口腔念珠菌病中，念珠菌性口腔念珠菌病（122例（39.3%））的数量超过其他形式。口腔病变患者的平均CD 4计数（207个细胞/mm（3））低于无口腔病变患者（291个细胞/mm（3））（P = 0.002）。口腔念珠菌病与CD 4细胞计数低于200个/mm 3显著相关（P = 0.000;比值比= 3.1; 95%置信区间1.9-4.9），具有良好的敏感性、最佳特异性和阳性预测值。口腔表现可作为替代CD 4计数在外地为基础的设置，以诊断艾滋病毒感染者的免疫功能低下的状态。
Human Immunodeficiency Virus (HIV)-related oral lesions can be used as markers of the immune status. The present cross-sectional study was conducted to identify the oral manifestations in HIV-infected individuals and their association with reduced Cluster of Differentiation 4 (CD4) count. The study population included known HIV-positive patients. A detailed case history of 399 HIV-positive patients was obtained and general examination was carried out. Diagnosis of oral lesions was done based on presumptive criteria of EEC Clearinghouse, 1993. The CD4 count was determined in 369 patients and correlated with oral manifestations. The prevalence of oral lesions was found to be 76.70% (n = 306). Oral candidiasis (157 (39.3%)) was the most common oral lesion associated with HIV infection. Amongst various forms of oral candidiasis, erythematous candidiasis (122 (39.3%)) outnumbered the other forms. The mean CD4 count of patients with oral lesions (207 cells/mm(3)) was less than in patients without oral lesions (291 cells/mm(3)) (P = 0.002). Oral candidiasis was found to be significantly correlated to a reduced CD4 cell count below 200 cells/mm(3) (P = 0.000; Odds ratio = 3.1; 95% Confidence interval 1.9-4.9) with good sensitivity, best specificity and positive predictive value. Oral manifestations may be used as an alternative to CD4 count at field-based settings to diagnose the immune compromised status of HIV-infected individuals.