Contextual fear discrimination is impaired by damage to the postrhinal or perirhinal cortex
Contextual fear discrimination is impaired by damage to the postrhinal or perirhinal cortex
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DOI：
10.1037//0735-7044.116.3.479
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发表时间：
2002-06-01
影响因子：
1.9
通讯作者：
Burwell, RD
中科院分区：
文献类型：
--
作者：
Bucci, DJ;Saddoris, MP;Burwell, RD
鼻后（POR）或鼻周围（PER）皮质损伤会损害情境恐惧的获得和表达，但损伤的性质尚不清楚。本研究使用情境恐惧辨别范式，使被试倾向于使用构形而非基本策略来区分两种情境，其中一种情境与轻度脚翘相匹配。对照大鼠在多个线索的组合下能够区分两种情境（实验1），但在单独的感官线索被操纵时不能区分（实验2）。POR或PER病变的大鼠在多种线索区分情境时不能区分休克和非休克情境（实验3）。结果表明，POR和PER在情境恐惧的构形学习中都有作用。
Postrhinal (POR) or perirhinal (PER) cortex damage impairs acquisition and expression of contextual fear, but the nature of the impairment remains unclear. This Study used a contextual fear discrimination paradigm that biased subjects toward using a configural, rather than an elemental, strategy to distinguish between 2 contexts, 1 of which was paired with a mild foot hock. Control rats discriminated between 2 contexts when a combination of several cues could be used (Experiment 1), but not when individual sensory cues were manipulated (Experiment 2). Rats with POR or PER lesions could not discriminate between the shock and no-shock contexts when multiple cues differentiated the contexts (Experiment 3). The results indicate that both the POR and PER have a role in configural learning of contextual fear.