CENTRAL ANTICONVULSANT EFFECTS OF MAGNESIUM-SULFATE ON N-METHYL-D-ASPARTATE INDUCED SEIZURES
CENTRAL ANTICONVULSANT EFFECTS OF MAGNESIUM-SULFATE ON N-METHYL-D-ASPARTATE INDUCED SEIZURES
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DOI：
10.1016/s0002-9378(12)90855-8
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发表时间：
1993-03-01
影响因子：
9.8
通讯作者：
BERMAN, RF
中科院分区：
文献类型：
--
作者：
COTTON, DB;HALLAK, M;BERMAN, RF
目的：本研究的目的是确定硫酸镁的中枢抗惊厥活性是否对N-甲基-D-天冬氨酸诱导的癫痫有效。研究设计：在两个不同的实验中，我们观察了硫酸镁抑制N-甲基-D-天冬氨酸诱导的大鼠海马区癫痫的能力。在第一个实验中，在颅内注射20杯N-甲基-D-天冬氨酸之前，外周注射硫酸镁。在第二个实验中，硫酸镁与N-甲基-D-天冬氨酸同时注入。结果：与生理盐水对照组相比，外周注射硫酸镁可显著延长大鼠从注射N-甲基-D-天冬氨酸至首次发作的潜伏期和持续升高2小时后的血清镁水平(P<；0.01)。首次发作的持续时间也显著缩短。脑内注射硫酸镁可显著延长癫痫发作潜伏期120%(p<；0.01)。总体而言，中心硫酸镁抑制了40%的动物癫痫发作活动(p<；0.01)。结论：硫酸镁对N-甲基-D-天冬氨酸诱导的大鼠海马癫痫发作具有中枢抗惊厥作用。
OBJECTIVE: The objective of this study was to determine if magnesium sulfate's central anticonvulsant activity is effective against N-methyl-D-aspartate-induced seizures.STUDY DESIGN: In two separate experiments we investigated magnesium sulfate's ability to inhibit N-methyl-D-aspartate-induced hippocampal seizures in rats. In the first experiment magnesium sulfate was administered peripherally before an intracranial injection of 20 mug of N-methyl-D-aspartate. In the second experiment magnesium sulfate was injected intracranially concurrently with N-methyl-D-aspartate. The ability of magnesium sulfate to suppress N-methyl-D-aspartate-induced seizure activity under both conditions was assessed.RESULTS: Peripherally administered magnesium sulfate significantly increased the latency from the time of an N-methyl-D-aspartate injection to the first seizure both by acute injection and after 2 hours of sustained elevation of serum magnesium levels when compared with saline solution-injected controls (p < 0.01). The duration of the first seizure was also significantly reduced. Intracranially administered magnesium sulfate significantly (p < 0.01) increased the seizure latency period by 120%. Overall, central magnesium sulfate prevented seizure activity in 40% of the animals (p < 0.01).CONCLUSION: Magnesium sulfate has a central anticonvulsant action on N-methyl-D-aspartate-induced seizures in this rat model of hippocampal seizures.