KIBRA gene variants are associated with episodic memory performance in subjective memory complaints
KIBRA gene variants are associated with episodic memory performance in subjective memory complaints
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DOI：
10.1016/j.neulet.2008.03.008
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发表时间：
2008-05-09
影响因子：
2.5
通讯作者：
Bracco, Laura
中科院分区：
文献类型：
--
作者：
Nacmias, Benedetta;Bessi, Valentina;Bracco, Laura
Kibra基因编码一种细胞质蛋白，是信号转导蛋白家族的成员，主要在大脑中表达。最近的研究表明，Kibra基因(T等位基因)的遗传变异与正常人的记忆有关，并与阿尔茨海默病(AD)的发病风险有关。我们报告了Kibra基因变异和载脂蛋白E(ApoE)84等位基因在报告日常记忆问题(主观记忆投诉)的老年人中的分布及其与神经心理学指标的关系。我们发现，在长期记忆测试中，携带CT/TT基因的SMC受试者比携带CC基因的受试者表现更差。因此，在我们看来，这些数据表明Kibra基因可能以一种不同的方式影响那些抱怨记忆缺陷的人的记忆表现，而不是那些不抱怨的人。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
The KIBRA gene encodes a cytoplasmatic protein, a member of the signal transduction protein family, expressed mainly in the brain. Recent studies have implicated the involvement of a genetic variation in the KIBRA gene (T allele) in human memory in normal subjects and in the risk of developing Alzheimer's disease (AD). We report here the distribution of the KIBRA genetic variant and the Apolipoprotein E (ApoE) 84 allele and their association with neuropsychological measures in older adults reporting problems with everyday memory (subjective memory complaints, SMC). We found that SMC subjects with the CT/TT genotype performed more poorly than those with the CC genotype on long-term memory tests. Thus, in our opinion, these data suggest that the KIBRA genotype could affect memory performance in a different way in those that complain of memory deficits compared to those that do not. (C) 2008 Elsevier Ireland Ltd. All rights reserved.