Stimulation with a Wireless Intraocular Epiretinal Implant Elicits Visual Percepts in Blind Humans
Stimulation with a Wireless Intraocular Epiretinal Implant Elicits Visual Percepts in Blind Humans
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DOI：
10.1167/iovs.09-4410
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发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Wachtler, Thomas
中科院分区：
文献类型：
--
作者：
Klauke, Susanne;Goertz, Michael;Wachtler, Thomas
目的.视网膜神经元的电刺激已被证明是一种可行的方式，以引起视网膜变性失明患者的视觉感知。EPIRET 3视网膜植入体是第一个用于视网膜前刺激的完全无线眼内植入体。在亚琛和埃森的眼科诊所进行的临床试验中进行了刺激试验，以评估植入物的安全性和有效性。本研究纳入了6名法定失明的视网膜色素变性患者。根据研究方案中规定的规定，在手术后4周内对每例受试者进行3次1小时感知测试。刺激是各种持续时间和电流幅度的电荷平衡方波电流脉冲。所有受试者均报告了植入物电刺激的视觉感知。诱发视觉感知的阈值在它们之间变化，但低于电刺激的安全限值。刺激的成功取决于脉冲持续时间比电流幅度或总电荷输送。受试者能够区分不同方向或电极阵列不同位置的刺激模式。EPIRET 3系统适用于失明视网膜色素变性患者的视觉感知。（Invest Ophthalmol维斯科学。2011; 52：449-455）DOI：10.1167/iovs.09-4410
PURPOSE. Electrical stimulation of retinal neurons has been shown to be a feasible way to elicit visual percepts in patients blind from retinal degenerations. The EPIRET3 retinal implant is the first completely wireless intraocular implant for epiretinal stimulation. Stimulation tests have been performed during a clinical trial that was carried out at the eye clinics of Aachen and Essen to evaluate the safety and the efficacy of the implant.METHODS. Six legally blind retinitis pigmentosa patients were included in the study. In accordance with the regulations laid down in the study protocol, three 1-hour perceptual tests for each subject were performed within 4 weeks of surgery. Stimuli were charge-balanced square current pulses of various durations and current amplitudes.RESULTS. All subjects reported visual percepts as a result of electrical stimulation by the implant. Thresholds for eliciting visual percepts varied between them but were below the safety limits of electrical stimulation. Stimulation success depended stronger on pulse duration than on current amplitude or total charge delivered. Subjects were able to discriminate between stimulation patterns of different orientations or at different locations of the electrode array.CONCLUSIONS. The EPIRET3 system is suitable to elicit visual percepts in blind retinitis pigmentosa patients. (Invest Ophthalmol Vis Sci. 2011; 52:449-455) DOI:10.1167/iovs.09-4410