DEVELOPMENT OF DIENCEPHALON IN RAT .2. CORRELATION OF EMBRYONIC-DEVELOPMENT OF HYPOTHALAMUS WITH TIME OF ORIGIN OF ITS NEURONS
DEVELOPMENT OF DIENCEPHALON IN RAT .2. CORRELATION OF EMBRYONIC-DEVELOPMENT OF HYPOTHALAMUS WITH TIME OF ORIGIN OF ITS NEURONS
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DOI：
10.1002/cne.901820512
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发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
BAYER, SA
中科院分区：
文献类型：
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作者：
ALTMAN, J;BAYER, SA
从第 13 天 (E13) 到出生前一天 (E22)，检查正常胚胎和 X 射线照射胚胎的下丘脑核发育情况。间脑神经上皮分为 3 个叶（背侧、内侧和腹侧）和 2 个小叶（上叶和下叶）。下丘脑源自腹侧叶和下小叶。腹侧神经上皮叶产生大多数早期出现的下丘脑结构的神经元，包括与内侧前脑束相关的外侧层核和异质中间层核的神经元。菱形脑室内衬的特殊神经上皮区域产生早期神经垂体大细胞神经元。室旁核的神经元保留在该位置，而视上核的神经元可以追踪到横向迁移。下丘脑后部晚期出现的促生理功能区的神经元源自下神经上皮小叶的成分，背内侧和腹内侧核显然来自下小叶主要部分的共享基质以及来自其后腹隐窝的结节乳头-弓形复合体。乳头系统的三层和顺序产生的组件可能来自不同的神经上皮部位。先前研究的放射自显影结果表明，成熟下丘脑的结构功能异质性与细胞遗传学异时性平行。下丘脑的许多可区分成分显然是由异质神经上皮位点的镶嵌体产生的。
The development of the nuclei of the hypothalamus was examined in normal and X-irradiated embryos from day 13 (E13) to the day before birth (E22). The diencephalic neuroepithelium was subdivided into 3 lobes (dorsal, medial, and ventral) and 2 lobules (superior and inferior). The hypothalamus is derived from the ventral lobe and the inferior lobule. The ventral neuroepithelial lobe generates the neurons of most of the early arising hypothalamic structures including those of the lateral tier nuclei associated with the medial forebrain bundle and the heterogeneous intermediate tier nuclei. A specialized neuroepithelial region lining the diamond shaped ventricle produces the early neurohypophysial magnocellular neurons. The neurons of the paraventricular nucleus remain at this site whereas the neurons of the supraoptic nucleus could be traced migrating laterally. The neurons of the late arising hypophysiotropic area of the posterior hypothalamus are derived from components of the inferior neuroepithelial lobule, the dorsomedial and ventromedial nuclei apparently from a shared matrix in the main portion of the inferior lobule and the tuberomammillary-arcuate complex from its posteroventral recess. The triple-decked and sequentially produced components of the mammillary system may arise from separate neuroepithelial sites. The autoradiographic results of the previous study showed that the structural functional heterogeneity of the mature hypothalamus is paralleled by cytogenetic heterochronicity. Many of the distinguishable components of the hypothalamus apparently arise from a mosaic of heterogeneous neuroepithelial sites.