BENT HELICAL STRUCTURE IN TRYPANOSOMA-LEWISI MINICIRCLES
BENT HELICAL STRUCTURE IN TRYPANOSOMA-LEWISI MINICIRCLES
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DOI：
10.1016/0309-1651(88)90050-1
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发表时间：
1988-10-01
期刊：
影响因子：
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通讯作者：
BATTAGLIA, PA
中科院分区：
文献类型：
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作者：
COSTANZO, G;BIRAGO, C;BATTAGLIA, PA
通过凝胶延迟测定和计算分析，我们证明了刘易斯锥虫的弯曲区域，位于两类不同的小圆中。我们表明，在每个小环中，这个弯曲区域都是独特的，邻近两个高度保守的区域之一，并以腺嘌呤延伸为特征。迄今为止测试的大多数锥虫小环都保留了相同的特性。因此，我们认为遗传信息可能位于小环DNA分子的确定结构中，而不是位于核苷酸序列中。
By gel retardation assay and computational analysis we demonstrated a bent region in Trypanosoma lewisi, localized in two different classes of minicircles. We showed that in each minicircle this bent region is unique, adjacent to one of two highly conserved regions and characterized by adenine stretches. The same properties are conserved in the majority of minicircles from Trypanosomes tested so far. Therefore, we suggest that the genetic information could be located in a definite structure of minicircle DNA molecules rather than in the nucleotide sequence.