Gel phantom for use in high-intensity focused ultrasound dosimetry
Gel phantom for use in high-intensity focused ultrasound dosimetry
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DOI：
10.1016/j.ultrasmedbio.2005.06.004
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发表时间：
2005-10-01
影响因子：
2.9
通讯作者：
Vaezy, S
中科院分区：
文献类型：
--
作者：
Lafon, C;Zderic, V;Vaezy, S
开发了一种光学透明的模体，用于高强度聚焦超声（US）或HIFU剂量学研究。幻影由聚丙烯酰胺水凝胶组成，嵌入牛血清白蛋白（BSA），该蛋白变性后变得光学不透明。声学和光学特性表征为BSA浓度和温度的函数。声速（1544 m/s）和声阻抗（1.6 MRayls）与软组织相似。衰减系数比软组织低约8倍（9% BSA为0.02 Np/cm/MHz）。非线性（B/A）系数与水中近似。在幻影形成过程中很容易看到HIFU病变。在美国b超图像中，只有当空化活动存在时，HIFU病变才被观察到为高回声区。在动物或临床研究之前，幻影可用于us图像引导HIFU设备的快速表征和校准。
An optically transparent phantom was developed for use in high-intensity focused ultrasound (US), or HIFU, dosimetry studies. The phantom is composed of polyacrylamide hydrogel, embedded with bovine serum albumin (BSA) that becomes optically opaque when denatured. Acoustic and optical properties of the phantom were characterized as a function of BSA concentration and temperature. The speed of sound (1544 m/s) and acoustic impedance (1.6 MRayls) were similar to the values in soft tissue. The attenuation coefficient was approximately 8 times lower than that of soft tissues (0.02 Np/cm/MHz for 9% BSA). The nonlinear (B/A) coefficient was similar to the value in water. HIFU lesions were readily seen during formation in the phantom. In US B-mode images, the HIFU lesions were observed as hyperechoic regions only if the cavitation activity was present. The phantom can be used for fast characterization and calibration of US-image guided HIFU devices before animal or clinical studies.