Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications.
Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications.
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DOI：
10.1039/c5cc03162a
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发表时间：
2015-06-30
期刊：
影响因子：
--
通讯作者：
Nilsson BL
中科院分区：
文献类型：
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作者：
Liyanage W;Vats K;Rajbhandary A;Benoit DS;Nilsson BL
Fmoc-3F-Phe-Arg-NH2 和 Fmoc-3F-Phe-Asp-OH 二肽进行共组装，形成双组分纳米原纤维水凝胶。这些水凝胶支持 NIH 3T3 成纤维细胞的活力和生长。 Arg 和 Asp 在纳米原纤维表面的超分子展示有效地模拟了纤连蛋白的整合素结合 RGD 肽，而 Arg 和 Asp 功能之间没有共价连接。
Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.