Endometrial CD16+ and CD16- NK Cell Count in Fertility and Unexplained Infertility
Endometrial CD16+ and CD16- NK Cell Count in Fertility and Unexplained Infertility
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DOI：
10.1111/aji.12132
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发表时间：
2013-09-01
影响因子：
3.6
通讯作者：
Gutierrez, Gabriela
中科院分区：
文献类型：
--
作者：
Junovich, Gisela;Azpiroz, Agustina;Gutierrez, Gabriela
ProblemPeripheral counts of CD16+ NK cells have been well characterized in reproductive failure. However, not enough case-control clinical studies have been conducted to establish normal or abnormal CD16+/- values in the endometrium.Method of studyPeripheral and endometrial NK cell counts by FACS, IL-6, and VEGF cytokines levels by ELISA were characterized in fertile women and unexplained infertility patients with implantation failures (UI-IF) during implantation window. ROC and correlation analysis were performed.ResultsReceiver Operating Characteristic(ROC) analysis revealed endometrial CD16+ NK cells, IL-6, and VEGF as good diagnostic parameters for unexplained infertility. Almost half of UI-FI patients showed increased total and CD16+ NK cell counts correlating with decreased levels of endometrial IL-6 and VEGF. No correlation was found with peripheral blood values.ConclusionIncreased CD16+ NK cells were associated with IL-6 and VEGF deficiency in a high proportion of UI-IF patients. Testing for these immunomarkers could be a potential tool in infertility diagnosis.
