ROLE OF OPIOID RECEPTORS IN BOMBESIN-INDUCED GROOMING
ROLE OF OPIOID RECEPTORS IN BOMBESIN-INDUCED GROOMING
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DOI：
10.1111/j.1749-6632.1988.tb38614.x
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发表时间：
1988-05-10
影响因子：
5.2
通讯作者：
COWAN, A
中科院分区：
文献类型：
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作者：
GMEREK, DE;COWAN, A
铃蟾肽是一种最初从青蛙 Bombinaombina 皮肤中分离出来的十四肽，当集中注射到大鼠2-以及其他物种^中时，会引起剂量相关的过度梳理行为。^ 脑室内（i.cv.）铃蟾肽在大鼠中引起的梳理行为包括主要针对头部和颈部的后肢抓挠，尽管面部梳理、身体清洗、舔指甲和咬指甲、前爪震颤、湿狗颤抖，也会发生拉伸。注射icv后几分钟内即可观察到铃蟾肽诱导的梳理行为，并持续30-45分钟。与由多种其他肽（例如 ACTHI-、、、促甲状腺素释放激素、P 物质、P-内啡肽和非肽，例如
Bombesin, a tetradecapeptide originally isolated from the skin of the frog Bombina bombina,’elicits dose-related excessive grooming when injected centrally in rats2-‘as well as other specie^.^ The grooming induced by intracerebroventricular (i. cv.) bombesin in rats consists of hindlimb scratching directed primarily at the head and neck, although facial grooming, body washing, nail licking and biting, forepaw tremors, wetdog shakes, and stretching also occur. Bombesin-induced grooming behavior can be observed within a few minutes of icv injection and continues for 30-45 minutes. In contrast to the grooming induced by a variety of other peptides such as ACTHI-,,, thyrotropin-releasing hormone, substance P, P-endorphin, and nonpeptides such as