A Negative Correlation Between Blood Glucose and Acetone Measured in Healthy and Type 1 Diabetes Mellitus Patient Breath.
A Negative Correlation Between Blood Glucose and Acetone Measured in Healthy and Type 1 Diabetes Mellitus Patient Breath.
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DOI：
10.1177/1932296815572366
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发表时间：
2015-07-01
影响因子：
5
通讯作者：
Rydosz, Artur
中科院分区：
文献类型：
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作者：
Rydosz, Artur
背景：呼出的丙酮分析长期以来被认为是诊断和监测糖尿病，特别是1型糖尿病的辅助工具。因此，确定呼出的丙酮浓度与血液中葡萄糖之间的关系是至关重要的。通常，这两种化合物之间的直接线性相关性是可以预料的。然而，在某些情况下，我们可以观察到负相关。当血糖升高时，呼气丙酮下降。方法：呼气分析作为糖尿病诊断和监测的辅助工具，只有在使用便携式分析仪的情况下才有意义。这种需求创造了气体传感器的市场。然而，商业上可用的丙酮气体传感器是为测量百万分之几十的样品而开发的。使用商用丙酮气体传感器(TGS 822,823 Figaro，Arlington Heights，IL，USA Inc.)和微型预浓度器在低温共烧陶瓷中测量呼出的丙酮浓度。使用HPR-20QIC(HPR-20QIC，Hiden Analytical，英国沃灵顿)。结果：22名无呼吸道疾病病史的健康志愿者和31名诊断为1型糖尿病的患者参与了研究。分别选择3例健康志愿者和5例趋势相反的1型糖尿病患者。线性拟合系数在0.1139~0.9573之间变化。因此，有必要确定血糖浓度与不同条件下的相关性，如胰岛素水平，并将结果与临床检查，如Hb1Ac.结论：众所周知，丙酮浓度受饮食、胰岛素治疗等因素的影响很大。因此，需要进行更复杂的长期测量分析。因此，目前的结果应该被视为试验性的，需要在包括对照组在内的大量患者中进行临床试验分析的验证性研究。
BACKGROUND: Exhaled acetone analysis has long been recognized as a supplementary tool for diagnosis and monitoring diabetes, especially type 1 diabetes. It is essential, therefore to determine the relationship between exhaled acetone concentration and glucose in blood. Usually, a direct linear correlation between this both compounds has been expected. However, in some cases we can observe a reverse correlation. When blood glucose was increasing, breath acetone declined.METHODS: The breath analysis as a supplementary tool for diagnosing and monitoring diabetes makes sense only in case of utilization of portable analyzers. This need has created a market for gas sensors. However, commercially available acetone gas sensors are developed for measuring samples at several tens part per million. The exhaled acetone concentration was measured using commercial acetone gas sensor (TGS 822, 823 Figaro, Arlington Heights, IL, USA Inc) with micropreconcentrator in low temperature cofired ceramics. The reference analyzer-mass spectrometry (HPR-20 QIC, Hiden Analytical, Warrington, UK) was used.RESULTS: Twenty-two healthy volunteers with no history of any respiratory disease participated in the research, as did 31 patients diagnosed with type 1 diabetes. Respectively, 3 healthy volunteer and 5 type 1 diabetes mellitus subjects with reverse trend were selected. The linear fitting coefficient various from 0.1139 to 0.9573. Therefore, it is necessary to determine the correlation between blood glucose concentrations and under different conditions, for example, insulin levels, as well as correlate the results with clinical tests, for example, Hb1Ac.CONCLUSIONS: It is well known that the concentration of acetone is strongly influenced by diet, insulin treatment, and so on. Therefore, much more complex analysis with long-term measurements are required. Thus, presented results should be regarded as tentative, and validation studies with the analysis of clinical test and in a large number of patients, including control groups, need to be carried out.