Maternal preconception phthalate metabolite concentrations in follicular fluid and neonatal birth weight conceived by women undergoing in vitro fertilization
Maternal preconception phthalate metabolite concentrations in follicular fluid and neonatal birth weight conceived by women undergoing in vitro fertilization
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母亲孕前卵泡液中邻苯二甲酸酯代谢物浓度和接受体外受精的妇女所怀的新生儿出生体重
DOI：
10.1016/j.envpol.2020.115584
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发表时间：
2020
影响因子：
8.9
通讯作者：
Guo Na
中科院分区：
文献类型：
--
作者：
Wu Lin-Jing;Teng Xue-Mei;Yao Yang-Cheng;Liu Chong;Du Yao-Yao;Deng Tao-Ran;Yuan Xiao-Qiong;Zeng Qiang;Li Yu-Feng;Guo Na
妊娠期间接触邻苯二甲酸盐与后代出生体重下降有关。然而，在接受体外受精 (IVF) 的女性中，卵泡液 (FF) 中的孕前邻苯二甲酸酯代谢物与后代出生体重之间的关系仍然很大程度上未知。在这里，我们探讨了 FF 中孕前邻苯二甲酸酯代谢物浓度与接受 IVF 的女性单胎和双胞胎的出生体重之间的关联。我们招募了 147 名女性参与者，她们于 2016 年 11 月至 12 月在武汉同济医院生殖医学中心生育了 90 名单胎婴儿和 57 名双胞胎婴儿。每位参与者都被要求在招募时填写一份调查问卷，并在卵母细胞取出当天提供 FF 样本。使用高效液相色谱和串联质谱法测定八种邻苯二甲酸酯代谢物的 FF 浓度。出生结果是从病历中提取的。使用广义线性模型（GLM）评估 FF 中邻苯二甲酸盐代谢物与单胎和双胞胎出生体重之间的关联。我们发现，双胞胎组的出生体重与FF中母亲孕前邻苯二甲酸单苄酯（MBzP）和邻苯二甲酸单（2-乙基-5-氧代己基）酯（MEOHP）呈负剂量反应相关（两者P趋势<0.05），而单胎组的出生体重与邻苯二甲酸单乙酯（MEP）和单（2-乙基-5-羟基己酯）呈正剂量反应相关。 FF 中的邻苯二甲酸盐 (MEHHP)（趋势 P 均 < 0.05）。当我们建模为连续变量时，这些关联仍然存在。此外，我们观察到双胞胎出生体重下降与 MEOHP 和 MBzP 之间存在男性特异性关联，而单胎出生体重增加与 MEP、MEHHP 和邻苯二甲酸二（2-乙基己酯）总和 (ΣDEHP) 之间存在女性特异性关联（交互作用的所有 P < 0.05）。母亲 FF 中的孕前邻苯二甲酸盐代谢物可能会影响单胎和双胞胎新生儿的出生体重。
Exposure to phthalates during gestation has been associated with decreased birth weight among offspring. However, the associations between preconception phthalate metabolites in follicular fluid (FF) and offspring birth weight among women undergoing in vitro fertilization (IVF) remain largely unknown. Here, we explored the associations between preconception phthalate metabolite concentrations in FF and the birth weights of singletons and twins among women undergoing IVF. We recruited 147 female participants who gave birth to 90 singletons and 57 twin infants at the Reproductive Medicine Center, Tongji Hospital, Wuhan, between November and December 2016. Each participant was asked to complete a questionnaire at the time of recruitment and provide a FF sample on the day of oocyte retrieval. The FF concentrations of eight phthalate metabolites were determined using high-performance liquid chromatography and tandem mass spectrometry. Birth outcomes were abstracted from medical records. The associations between phthalate metabolites in FF and birth weights of the singleton and twin groups were evaluated using generalized linear models (GLMs). We found that birth weight in the twin group had negative dose-response associations with maternal preconception monobenzyl phthalate (MBzP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) in FF (bothPfor trends < 0.05) and that birth weight in the singleton group had positive dose-response associations with monoethyl phthalate (MEP) and mono(2-ethyl-5 hydroxyhexyl) phthalate (MEHHP) in FF (bothPfor trends < 0.05). These associations persisted when we modeled as continuous variables. In addition, we observed male-specific association between decreased twin birth weight and MEOHP and MBzP and a female-specific associations between increased singleton birth weight and MEP, MEHHP and the sum of di(2-ethylhexyl) phthalate (∑DEHP) (allPfor interactions < 0.05). Preconception phthalate metabolites in maternal FF may affect the birth weights of both singleton and twin newborns.