Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis
Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis
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DOI：
10.1111/j.1872-034x.2011.00883.x
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发表时间：
2011-12-01
影响因子：
4.2
通讯作者：
Saibara, Toshiji
中科院分区：
文献类型：
--
作者：
Ono, Masafumi;Ochi, Tsunehiro;Saibara, Toshiji
目的：非酒精性脂肪性肝炎（NASH）患者经常患有高血压，这被认为是随后发生肝纤维化的重要预测因素。还已知肾素-血管紧张素系统促进NASH的进展。已提出参与NASH发展的各种类型的功能性单核苷酸多态性（SNP）。血管紧张素原（Angiotensinogen，AGT）基因SNPs与心血管疾病相关已有报道。我们的目的是评估AGT基因单倍型在日本NASH患者中的参与。
Aim: Non-alcoholic steatohepatitis (NASH) patients frequently have hypertension, which is considered to be an important predictive factor for the subsequent development of hepatic fibrosis. The renin-angiotensin system is also known to contribute to the progression of NASH. Various types of functional single-nucleotide polymorphisms (SNPs) involved in the development of NASH have been proposed. Angiotensinogen (AGT) gene SNPs related to cardiovascular diseases have been reported. We aimed to evaluate the involvement of the AGT gene haplotype in Japanese NASH patients.