Electronic dura mater for long-term multimodal neural interfaces
Electronic dura mater for long-term multimodal neural interfaces
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DOI：
10.1126/science.1260318
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发表时间：
2015-01-09
期刊：
影响因子：
56.9
通讯作者：
Lacour, Stephanie P.
中科院分区：
文献类型：
--
作者：
Minev, Ivan R.;Musienko, Pavel;Lacour, Stephanie P.
软神经组织和硬神经植入物之间的机械不匹配阻碍了植入式神经假体的长期性能。在这里，我们设计和制造了软神经植入物的形状和弹性的硬脑膜，大脑和脊髓的保护膜。电子硬脑膜，我们称之为e-dura，嵌入了互连，电极和化学电极，可维持数百万次机械拉伸周期，电刺激脉冲和化学注射。这些集成的模态使多种神经假体应用成为可能。软植入物提取自由行为动物的皮层状态用于脑-机接口，并提供电化学脊髓神经调节，以恢复瘫痪脊髓损伤后的运动。
The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord. The electronic dura mater, which we call e-dura, embeds interconnects, electrodes, and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections. These integrated modalities enable multiple neuroprosthetic applications. The soft implants extracted cortical states in freely behaving animals for brain-machine interface and delivered electrochemical spinal neuromodulation that restored locomotion after paralyzing spinal cord injury.