Medication-adherence predictors among patients with tuberculosis or human immunodeficiency virus infection in Burkina Faso
Medication-adherence predictors among patients with tuberculosis or human immunodeficiency virus infection in Burkina Faso
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DOI：
10.1016/j.jmii.2013.05.001
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发表时间：
2014-06-01
影响因子：
7.4
通讯作者：
Chen, Yi-Ming Arthur
中科院分区：
文献类型：
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作者：
Meda, Ziemle Clement;Lin, Yu-Ting;Chen, Yi-Ming Arthur
背景：坚持治疗仍然是结核病 (TB) 和人类免疫缺陷病毒 (HIV) 项目的一个关键问题。研究目的是确定结核病、艾滋病毒或两者兼有的患者服药依从性 (MA) 的潜在决定因素。方法：在这项横断面研究中，招募了 2010 年 8 月至 10 月在布基纳法索两个主要地区（中部和上巴斯辛）就诊的结核病或艾滋病毒诊所的成年患者。收集了问卷，并使用简单和多元逐步线性回归模型来确定 MA 的预测因素。 1043 名患者（309 名结核病患者、553 名艾滋病毒患者以及 181 名两者同时感染）参与了这项研究。对于结核病患者来说，良好 MA 的调整预测因素包括不饮酒、曾经失访以及对疾病传播的认识。对于艾滋病毒感染者来说，良好 MA 的调整预测因素包括较少的耻辱感、对结核病传播的良好了解以及对疾病传播的认识。对于双重感染的患者，良好 MA 的调整预测因子是良好的态度。此外，结核病或双重感染患者的 MA 较差的调整预测因素分别是获得护理的经济能力较差和在家中睡觉的人数较多。结论：本研究提供了感染结核病、艾滋病毒以及同时感染结核病和艾滋病毒的患者的 MA 信息。结核病和艾滋病毒规划必须考虑患者的环境及其特征，包括耻辱、态度、失访状况、结核病知识、获得护理的经济能力、饮酒、对疾病传播的认识以及在家中睡觉的人数。本研究中确定的这些因素需要针对特定的患者概况以及在敏化、项目规划和研究阶段加以考虑。版权所有(C) 2013，台湾微生物学会。由爱思唯尔台湾有限公司出版。版权所有。
Background: Adherence to treatment remains a key issue for tuberculosis (TB) and human immunodeficiency virus (HIV) programs. The study objective was to identify potential determinants of medication adherence (MA) among patients with TB, HIV, or both.Methods: In this cross-sectional study, adult patients attending TB or HIV clinics were recruited in two main regions (Centre and Hauts-Bassins) of Burkina Faso from August to October 2010. Questionnaires were collected and simple and multiple step-wise linear regression models were used to identify predictors of MA.Results: In total, 1043 patients (309 with TB, 553 with HIV, and 181 coinfected with both) participated in this study. For patients with TB, adjusted predictors of good MA were no alcohol use, ever been lost to follow-up, and awareness of disease transmission. For patients with HIV, adjusted predictors of good MA were less stigma, good knowledge about TB transmission, and awareness of disease transmission. For patients with dual infection, adjusted predictors of good MA was good attitude. Furthermore, adjusted predictors of poor MA for patients with TB or with dual infection were poor financial access to care and high number of persons sleeping in the household, respectively.Conclusion: This study provides information on MA in patients infected with TB, HIV, and those coinfected with TB and HIV. TB and HIV programs have to consider the environment of the patient and its characteristics, including stigma, attitude, status of loss to follow-up, TB knowledge, financial access to care, alcohol use, awareness of disease transmission, and number of persons sleeping in the household. These identified factors in this study need to be taken into account for a specific patient profile and during sensitization, project planning, and research stages. Copyright (C) 2013, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved.