Functions of the tegument of schistosomes: Clues from the proteome and lipidome
Functions of the tegument of schistosomes: Clues from the proteome and lipidome
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DOI：
10.1016/j.ijpara.2006.01.007
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发表时间：
2006-05-31
影响因子：
4
通讯作者：
Tielens, Aloysius G. M.
中科院分区：
文献类型：
--
作者：
Van Hellemond, Jaap J.;Retra, Kim;Tielens, Aloysius G. M.
寄生虫体的外表面是一种独特的双层膜结构，对调节宿主反应和寄生虫存活至关重要。虽然一些被膜蛋白已确定了经典的生化方法，知识的整个分子组成的被膜是有限的。曼氏血吸虫基因组计划，连同最近开发的蛋白质组学和脂质组学技术，允许研究的蛋白质和脂质的皮层膜的详细特征。这些研究确定了皮层蛋白质和脂质，证实了皮层在营养吸收和免疫逃避中的功能。然而，这些研究也表明，与完整的蠕虫相比，皮层富含宿主中不存在的脂质。被膜也富含与除染色体以外的物种数据库中存在的任何序列不具有序列相似性的蛋白质。这些结果表明，独特的皮层结构包括多个独特的组件，可能履行尚未未知的功能。因此，被膜蛋白质组和脂质组意味着许多未知的分子机制是由寄生体在其宿主中生存。(c)2006年澳大利亚寄生虫学会有限公司出版的爱思唯尔有限公司保留所有权利。
The tegumental outer-surface of schistosomes is a unique double membrane structure that is of crucial importance for modulation of the host response and parasite survival. Although several tegumental proteins had been identified by classical biochemical approaches, knowledge on the entire molecular composition of the tegument was limited. The Schistosoma mansoni genome project, together with recently developed proteomic and lipidomic techniques, allowed studies on detailed characterisation of the proteins and lipids of the tegumental membranes. These studies identified tegumental proteins and lipids that confirm the function of the tegument in nutrient uptake and immune evasion. However, these studies also demonstrated that compared to the complete worm, the tegument is enriched in lipids that are absent in the host. The tegument is also enriched in proteins that share no sequence similarity to any sequence present in databases of species other than schistosomes. These results suggest that the unique tegumental structures comprise multiple unique components that are likely to fulfil yet unknown functions. The tegumental proteome and lipidome, therefore, imply that many unknown molecular mechanisms are employed by schistosomes to survive within their host. (c) 2006 Australian Society for Parasitology Inc Published by Elsevier Ltd. All rights reserved.