Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
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DOI：
10.1359/jbmr.060507
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发表时间：
2006-08-01
影响因子：
6.2
通讯作者：
Finkelstein, Joel S.
中科院分区：
文献类型：
--
作者：
Burnett, Sherri-Ann M.;Gunawardene, Samantha C.;Finkelstein, Joel S.
FGF-23是一种新型的磷酸盐代谢调节剂。我们使用两种测定法研究了66名男性和女性的膳食磷酸盐对FGF-23的调节作用。膳食磷酸盐限制降低FGF-23和负荷增加FGF-23显着。测量完整FGF-23的测定比也测量假定的生物学无活性片段的测定更清楚地显示膳食磷酸盐的影响。膳食磷酸盐是循环FGF-23的关键调节剂;在研究FGF-23生理学时，测定方法的选择至关重要。
FGF-23 is a novel regulator of phosphate metabolism. We studied the regulation of FGF-23 by dietary phosphate in 66 men and women using two assays. Dietary phosphate restriction decreased FGF-23 and loading increased FGF-23 significantly. An assay that measured intact FGF-23 showed the effects of dietary phosphate much more clearly than an assay that also measures presumed biologically inactive fragments. Dietary phosphate is a key regulator of circulating FGF-23; choice of assay is critical when studying FGF-23 physiology.