EPSTEIN-BARR-VIRUS GENOTYPES ASSOCIATED WITH NASOPHARYNGEAL CARCINOMA IN SOUTHERN CHINA
EPSTEIN-BARR-VIRUS GENOTYPES ASSOCIATED WITH NASOPHARYNGEAL CARCINOMA IN SOUTHERN CHINA
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DOI：
10.1016/0042-6822(90)90458-4
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发表时间：
1990-07-01
期刊：
影响因子：
3.7
通讯作者：
NG, MH
中科院分区：
文献类型：
--
作者：
LUNG, ML;CHANG, RS;NG, MH
我们使用了约三分之二的EB病毒基因组的探针来检测直接从中国南部的28例鼻咽癌组织中检测到的野生型EB病毒的遗传多态性。在包含重复序列的高变区中，这一分析表明，尽管自然产生的病毒在遗传上是多样化的，但在每个肿瘤标本中只检测到了基因型。在EBV基因组的四个区域检测到鼻咽癌中独特的变异。其中两个似乎在它们的分布中具有重要意义。由BamHIW1*和I1*区之间的BamHI位点缺失引起的C型变异在中国南部的分离株中很常见，但在美国并不常见。在BamHI F区有一个额外的BamHI位点的“f”变体也几乎只在亚洲鼻咽癌活检组织中被检测到。
We have used probes representing approximately two-thirds of the Epstein-Barr virus (EBV) genome to examine genetic polymorphism of wild-type EBV directly detected in 28 nasopharyngeal carcinoma (NPC) tissues from Southern China. In the hypervariable regions containing reiterated sequences, this analysis showed that while naturally occurring viruses are genetically diverse, only genotype was detectable in each tumor specimen. Unique variants in NPC were detected in four regions of the EBV genome. Two of these appeared significant in their distribution. The type C variant resulting from loss of a BamHI site betweenthe BamHI W1* and I1* regions was prevalent among isolates from Southern China, but not so common in the United States. An "f" variant having an extra BamHI site in the BamHI F region was alsmost exclusively detected in only Asian NPC biopsies.