Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin-resistant fructose-fed rat
Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin-resistant fructose-fed rat
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DOI：
10.1021/jf049295g
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发表时间：
2004-09-08
影响因子：
6.1
通讯作者：
Teissedre, PL
中科院分区：
文献类型：
--
作者：
Al-Awwadi, NA;Bornet, A;Teissedre, PL
红葡萄酒多酚提取物（RWPE），乙醇，或两者结合的影响进行了评估，在胰岛素抵抗大鼠。用富含果糖（60%）的食物喂养大鼠6周，并用（a）仅水（F组）、（B）RWPE水溶液（1100 mg/kg，FP组）、（c）10%（v/v）乙醇和水的混合物（FE组）或（d）含有相同量的RWPE和乙醇的溶液（FPE组）强制喂养大鼠。以标准食物喂养的动物（C组）用于比较目的。6周后，IF组的血压（130.0 xb 1 1.7 mm Hg）高于C组动物（109.6 xb 1 0.9 mm Hg），并且在所有其他果糖喂养治疗组中与C组相似。IF动物的相对心脏重量（3.10 xb10.05）高于C动物（2.78 xb10.07），FP动物（2.92 xb10.04）和FPE动物（2.87 xb10.08 mg/g）的相对心脏重量显著低于F动物。左心室和主动脉产生活性氧（O-2（.-））IF组高于C组，RWPE组降低，而乙醇处理组无此作用。乙醇而不是RWPE治疗降低了果糖喂养大鼠的胰岛素抵抗程度。总之，我们的研究表明，多酚能够防止胰岛素抵抗果糖喂养大鼠的心脏肥大和活性氧的产生。
The effects of a red wine polyphenolic extract (RWPE), ethanol, or both combined were evaluated in insulin resistant rats. Rats were fed for 6 weeks with fructose (60%)-enriched food and force-fed with (a) water only (F group), (b) aqueous solution of RWPE (1100 mg/kg, FP group), (c) 10% (v/v) mixture of ethanol and water (FE group), or (d) solution containing the same amount of the RWPE and ethanol (FPE group). Animals fed a standard chow (C group) were used for comparison purpose. After 6 weeks, blood pressure was higher in IF (130.0 xb1 1.7 mm Hg) than in C animals (109.6 xb1 0.9 mm Hg) and similar to the C group in all other fructose-fed treatment groups. Relative heart weight was higher in IF (3.10 xb1 0.05) than in C (2.78 xb1 0.07) and significantly lower in FP (2.92 xb1 0.04) and FPE (2.87 xb1 0.08 mg/g) than in F animals. Left ventricle and aorta productions of reactive oxygen species (O-2(.-)) were higher in IF than in C groups and lowered by the RWPE but not by the ethanol treatment. Ethanol but not the RWPE treatment reduced the degree of insulin resistance in the fructose-fed rats. In summary, our study showed that polyphenols are able to prevent cardiac hypertrophy and production of reactive oxygen species in the insulin resistant fructose-fed rat.