The Genetic Diversity of HIV-1 Within Antiretroviral-Naive Outpatients in Ganzhou, China.
The Genetic Diversity of HIV-1 Within Antiretroviral-Naive Outpatients in Ganzhou, China.
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中国赣州未接受过抗逆转录病毒治疗的门诊患者中 HIV-1 的遗传多样性。
DOI：
10.1089/aid.2020.0168
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发表时间：
2021
影响因子：
1.5
通讯作者：
Chen Xin
中科院分区：
文献类型：
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作者：
Xie Ying-Na;Zhang Yu-Ning;Cheng Si-Wei;Huang Dan-Dan;Xie Bing-Yu;Huang Zhen;Zhou Yan-Heng;Zhu Da-Qing;Chen Xin
为探讨中国赣州市人类免疫缺陷病毒1型（HIV-1）的分子流行病学状况，于2018年7月5日至21日招募了8名HIV-1阳性门诊患者。从患者抗逆转录病毒治疗前收集的血浆样本中扩增并测序了6个HIV-1近全长序列。系统发育分析和bootscan分析显示，其中一个序列是CRF01_AE，一个是CRF55_01B，两个是CRF07_BC。值得注意的是，其中一个序列是独特的重组形式，其中一个是CRF07_BC和C亚型的第二代重组形式。这些结果表明，多种HIV-1亚型在中国赣州流行。因此，迫切需要开展大样本量的系统性调查，以明确赣州地区HIV-1的分子流行病学特征，并追踪其来源。
To explore the molecular epidemiological status of human immunodeficiency virus type 1 (HIV-1) in Ganzhou, China, eight HIV-1–positive outpatients were recruited from July 5 to 21, 2018. Six HIV-1 near-full-length sequences were amplified and sequenced from the plasma samples that were collected before the patients' antiretroviral treatments. Phylogenetic and bootscan analyses revealed that one of the sequences was CRF01_AE, one was CRF55_01B, and two were CRF07_BC. Notably, one of the sequences was a unique recombinant form, and one of them was a second-generation recombinant form of CRF07_BC and subtype C. These results revealed that multiple HIV-1 subtypes are circulating in Ganzhou, China. Systematic surveys with large sample sizes are urgently needed to explore the exact molecular epidemiological characteristics and to trace the origins of HIV-1 in Ganzhou, China.