Oleanane-type Triterpenes with Highly-Substituted Oxygen Functional Groups from the Flower Buds of Camellia sinensis and Their Inhibitory Effects against NO Production and HSV-1
Oleanane-type Triterpenes with Highly-Substituted Oxygen Functional Groups from the Flower Buds of Camellia sinensis and Their Inhibitory Effects against NO Production and HSV-1
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DOI：
10.1177/1934578x1801300206
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发表时间：
2018-02
影响因子：
1.8
通讯作者：
Taichi Yoneda;Seikou Nakamura;Keiko Ogawa;Tomoko Matsumoto;Souichi Nakashima;K. Matsumura;A. Tanaka;Kaori Ryu;M. Fukaya;M. Fujimuro;M. Yoshikawa;H. Matsuda
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文献类型：
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作者：
Taichi Yoneda;Seikou Nakamura;Keiko Ogawa;Tomoko Matsumoto;Souichi Nakashima;K. Matsumura;A. Tanaka;Kaori Ryu;M. Fukaya;M. Fujimuro;M. Yoshikawa;H. Matsuda
从茶树（Camellia sinensis）花蕾提取物的水解产物中分离得到三个酰基化的齐墩果烷型三萜化合物，分别命名为chakasapogenins I（1）、II（2）和III（3）。根据化学和物理化学证据鉴定了新的三萜化合物的化学结构。chakasapogenin III（3）抑制脂多糖（LPS）激活的RAW 264.7巨噬细胞中一氧化氮（NO）的产生。此外，R1-barrigenol（7）在10μM时对单纯疱疹病毒1型（HSV-1）显示出抗病毒作用。
Acylated oleanane-type triterpenes named chakasapogenins I (1), II (2), and III (3) were isolated from the hydrolysis product of the extract obtained from the flower buds of Camellia sinensis. The chemical structures of new triterpenes were elucidated on the basis of chemical and physicochemical evidence. chakasapogenin III (3) inhibited nitric oxide (NO) production in lipopolysaccharide- (LPS) activated RAW264.7 macrophages. In addition, R1-barrigenol (7) showed antiviral effect at 10μM against herpes simplex virus type-1 (HSV-1).