Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during "abstinence"
Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during "abstinence"
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DOI：
10.1016/j.alcohol.2006.06.007
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发表时间：
2006-04-01
期刊：
影响因子：
2.3
通讯作者：
Raskind, Murray A.
中科院分区：
文献类型：
--
作者：
Rasmussen, Dennis D.;Wilkinson, Charles W.;Raskind, Murray A.
我们已经报道，重复的每日乙醇消费增加焦虑样行为的大鼠4周后，乙醇消费已经停止，与持续增加的焦虑表现出的禁欲酗酒者。焦虑的增加与交感肾上腺的激活有关，因此我们现在也研究了乙醇诱导的基础和应激诱导的血浆肾上腺素（E）和去甲肾上腺素（NE）水平的持续变化。雄性Sprague-Dawley大鼠接受含乙醇的液体饮食与配对喂养的等热量对照液体饮食，持续9周。在随后的5周“禁欲”（即，饮食中无乙醇），对照组大鼠表现出低的基础血浆E和NE，在转移到新房间中的新笼子后5分钟内两者均增加150-300%，在15分钟内恢复到基础水平。“戒断”乙醇处理的大鼠表现出升高的基础E水平（对照组的195%，P <0.05），转移到新环境中没有显著改变;基础NE水平倾向于升高（P <0.07），同样没有被新环境改变。这些结果表明，每日饮酒可以诱导持续增加交感肾上腺激活在随后的“禁欲”，这是相对难治进一步的刺激。(c)2006年爱思唯尔公司All rights reserved.
We have reported that repetitive daily ethanol consumption increased anxiety-like behavior in rats 4 weeks after ethanol consumption had ceased, consistent with the persistently increased anxiety exhibited by abstinent alcoholics. Increased anxiety is associated with sympathoadrenal activation, so we have now also investigated ethanol-induced persistent changes in basal and stress-induced plasma epinephrine (E) and norepinephrine (NE) levels. Male Sprague-Dawley rats received liquid diet containing ethanol versus pair-fed isocaloric control liquid diet for 9 weeks. After 5 weeks' subsequent "abstinence" (i.e., no ethanol in the diet), the control rats exhibited low basal plasma E and NE, which were both increased by 150-300% within 5 min after transfer to a novel cage in a novel room, returning toward basal levels within 15 min. "Abstinent" ethanol-treated rats exhibited elevated basal E levels (195% of controls, P < .05), which were not significantly altered by transfer to novel environment; basal NE levels tended (P < .07) to be elevated and likewise were not altered by novel environment. These results suggest that daily ethanol consumption can induce persistent increases in sympathoadrenal activation during subsequent "abstinence," which are relatively refractory to further stimulation. (c) 2006 Elsevier Inc. All rights reserved.