Tetrahymena Expresses More than a Hundred Proteins with Lipid‐binding MORN Motifs that can Differ in their Subcellular Localisations
Tetrahymena Expresses More than a Hundred Proteins with Lipid‐binding MORN Motifs that can Differ in their Subcellular Localisations
复制标题
DOI：
10.1111/jeu.12216
复制
发表时间：
2015-09
影响因子：
2.2
通讯作者：
J. Habicht;Christian Woehle;Sven B. Gould
中科院分区：
文献类型：
--
作者：
J. Habicht;Christian Woehle;Sven B. Gould
具有膜占据和识别连接（MORN）基序的蛋白质与顶复门寄生虫的细胞分裂、拟南芥的叶绿体分裂和精细胞的运动有关。我们发现纤毛虫是编码MORN蛋白种类最多的纤毛虫之一。嗜热四膜虫表达129个MORN蛋白编码基因，其中一些在接合过程中特异性上调。脂质结合测定支持MORN基序本身的主要功能是赋予脂质结合能力的假设。四个MORN候选蛋白具有相似的特征的本地化突出了这一组的功能多样性，特别是在纤毛虫。
Proteins with membrane occupation and recognition nexus (MORN) motifs are associated with cell fission in apicomplexan parasites, chloroplast division in Arabidopsis and the motility of sperm cells. We found that ciliates are among those that encode the largest variety of MORN proteins. Tetrahymena thermophila expresses 129 MORN protein‐encoding genes, some of which are specifically up‐regulated during conjugation. A lipid‐binding assay underpins the assumption that the predominant function of MORN motifs themselves is to confer the ability of lipid binding. The localisation of four MORN candidate proteins with similar characteristics highlights the functional diversity of this group especially in ciliates.