Inflammaging as a major characteristic of old people: Can it be prevented or cured?
Inflammaging as a major characteristic of old people: Can it be prevented or cured?
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DOI：
10.1111/j.1753-4887.2007.tb00358.x
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发表时间：
2007-12-01
影响因子：
6.1
通讯作者：
Franceschi, Claudio
中科院分区：
文献类型：
--
作者：
Franceschi, Claudio
人口普遍老龄化是富裕社会新近出现的现象。炎症是应对有害物质的必要条件，对生存至关重要，特别是在我们的生育年龄应对急性炎症。但是，长期暴露于各种抗原，特别是某些病毒，如巨细胞病毒，时间比进化预测的要长得多，就会诱发慢性低度炎症状态，从而导致与年龄相关的发病率和死亡率。这种情况被称为“炎症”。百岁老人的独特之处在于，尽管他们的促炎标志物水平很高，但他们也表现出抗炎标志物，这可能会延缓疾病的发作。成功衰老和长寿的关键是减少慢性炎症，同时不影响暴露于病原体时的急性反应。
Widespread aging at the population level is a recent phenomenon that emerged in affluent societies. Inflammation is necessary to cope with damaging agents and is crucial for survival, particularly to cope with acute inflammation during our reproductive years. But chronic exposure to a variety of antigens, especially to some viruses such as cytomegalovirus, for a period much longer than that predicted by evolution, induces a chronic low-grade inflammatory status that contributes to age-associated morbidity and mortality. This condition carries the proposed name "inflammaging". Centenarians are unique, in that, despite high levels of pro-inflammatory markers, they also exhibit anti-inflammatory markers that may delay disease onset. The key to successful aging and longevity is to decrease chronic inflammation without compromising an acute response when exposed to pathogens.