Gene duplication and the evolution of moonlighting proteins.
Gene duplication and the evolution of moonlighting proteins.
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DOI：
10.3389/fgene.2015.00227
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发表时间：
2015
影响因子：
3.7
通讯作者：
DeLuna A
中科院分区：
文献类型：
--
作者：
Espinosa-Cantú A;Ascencio D;Barona-Gómez F;DeLuna A
基因复制是基因组进化中反复出现的现象，也是获得生物功能的主要驱动力。在这里，我们研究基因复制的起源和维护的兼职蛋白质的作用，特别关注功能冗余和创新，分子权衡和遗传鲁棒性。对具体例子的概述主要来自酵母表明，经过漫长的进化时间，重复基因中的兼职行为得到了广泛的保护。剂量放大和不完全亚功能化似乎是普遍的多功能性的维护。我们讨论的作用，基因表达的分歧和parabolic反应在兼职蛋白质重叠的生化特性。未来的研究以更系统和全面的方式分析多功能基因，不仅可以更好地理解这类新兴的蛋白质行为是如何起源和维持的，而且还可以为基因复制的进化机制提供新的见解。
Gene duplication is a recurring phenomenon in genome evolution and a major driving force in the gain of biological functions. Here, we examine the role of gene duplication in the origin and maintenance of moonlighting proteins, with special focus on functional redundancy and innovation, molecular tradeoffs, and genetic robustness. An overview of specific examples-mainly from yeast-suggests a widespread conservation of moonlighting behavior in duplicate genes after long evolutionary times. Dosage amplification and incomplete subfunctionalization appear to be prevalent in the maintenance of multifunctionality. We discuss the role of gene-expression divergence and paralog responsiveness in moonlighting proteins with overlapping biochemical properties. Future studies analyzing multifunctional genes in a more systematic and comprehensive manner will not only enable a better understanding of how this emerging class of protein behavior originates and is maintained, but also provide new insights on the mechanisms of evolution by gene duplication.
影响因子：
5.7
作者：
Barona-Gómez F
通讯作者：
Barona-Gómez F