Association between gut microbiota composition and glycoalbumin level during pregnancy in Japanese women: Pilot study from Chiba Study of Mother and Child Health.
Association between gut microbiota composition and glycoalbumin level during pregnancy in Japanese women: Pilot study from Chiba Study of Mother and Child Health.
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日本女性怀孕期间肠道微生物群组成与糖白蛋白水平之间的关联：千叶母婴健康研究的初步研究。
DOI：
10.1111/jdi.13177
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Mori C
中科院分区：
文献类型：
--
作者：
Sakurai K;Kato T;Tanabe H;Taguchi-Atarashi N;Sato Y;Eguchi A;Watanabe M;Ohno H;Mori C
目的/介绍肠道菌群对人体健康有多种影响。先前的一些报告表明，肠道微生物群在怀孕期间发生变化并影响新陈代谢，但其他报告表明微生物群不会改变。在这里，我们检查了45名怀孕期间健康的日本妇女的肠道微生物群和糖蛋白水平。材料与方法对孕妇粪便样本进行16S rRNA基因测序分析，比较妊娠早期和晚期孕妇粪便样本的肠道菌群组成。我们还研究了肠道微生物群与母体特征（包括糖白蛋白）之间的关系。结果经加权和未加权UniFrac距离主坐标分析，妊娠早期和晚期微生物群组成无显著差异。香农指数在妊娠早期和晚期无显著差异。妊娠后期与妊娠早期相比，TM7门的比例明显下降，但其他主要门的比例没有变化。经协变量调整后，孕晚期Shannon指数与孕前体重指数呈负相关，与糖蛋白水平呈正相关。结论日本女性妊娠期肠道菌群差异不明显，除TM7外，肠道菌群多样性可能影响母体代谢。由于本研究的统计效力有限，需要进一步的大规模研究。
Aims/IntroductionGut microbiota have various effects on human health. Some previous reports have shown that gut microbiota change during pregnancy and affect metabolism, but others have shown that microbiota do not change. Here, we examined the gut microbiota and glycoalbumin levels of 45 healthy Japanese women during pregnancy.Materials and MethodsWe carried out 16S rRNA gene sequencing analyses of maternal stool samples and compared the gut microbiota composition of samples from women in early and late pregnancy. We also examined the association between gut microbiota and maternal characteristics, including glycoalbumin.ResultsMicrobiota composition in early and late pregnancy did not differ, according to principal coordinate analysis of weighted and unweighted UniFrac distances. Shannon indices were not different between early and late pregnancy. The proportion of one phylum, TM7, significantly decreased in late pregnancy compared with early pregnancy, but the proportions of other major phyla did not change. The Shannon index of late pregnancy was negatively associated with pregestational body mass index and positively correlated with glycoalbumin level, with adjustment of covariates.ConclusionsWe concluded that Japanese women did not show obvious differences in gut microbiota during pregnancy, except for TM7, and that the diversity of gut microbiota might affect maternal metabolism. As this study had limited statistical power, further large‐scale studies are required.