CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
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DOI：
10.1073/pnas.0707585104
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发表时间：
2007-10-23
影响因子：
11.1
通讯作者：
Koob, George F.
中科院分区：
文献类型：
--
作者：
George, Olivier;Ghozland, Sandy;Koob, George F.
尼古丁是烟草的主要精神活性成分，在戒烟期间会引发负面情绪症状，导致对尼古丁的强烈渴望。然而，尼古丁产生依赖的神经生物学机制仍然知之甚少。我们通过招募下丘脑外应激肽促肾上腺皮质激素释放因子(CRF)系统和激活CRF受体，证明了戒断后观察到的焦虑样戒断症状和过量尼古丁摄入的一种机制。CRF-CRF1系统的过度激活可能导致尼古丁依赖，并可能成为研究烟草成瘾易感性的重要目标。
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extra hypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF, receptors. Overactivation of the CRF-CRF1 system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction.