An ecological evaluation of the increasing incidence of endometrial cancer and the obesity epidemic
An ecological evaluation of the increasing incidence of endometrial cancer and the obesity epidemic
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DOI：
10.1016/j.ajog.2020.10.042
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发表时间：
2021-04-30
影响因子：
9.8
通讯作者：
Salani, Ritu
中科院分区：
文献类型：
--
作者：
Smrz, Stacy A.;Calo, Corinne;Salani, Ritu
背景技术背景：近几十年来，肥胖的患病率显著增加，尤其是在年轻女性中，肥胖是子宫内膜癌的一个已知危险因素。目的：本研究旨在评估肥胖患病率和I型子宫内膜癌发病率在不同年龄组中随时间的变化趋势，以确定是否存在生态关系。数据来自监测、流行病学和最终结果计划以及国家健康和营养检查调查。从1988年到2016年，观察了1型子宫内膜癌发病率和肥胖患病率的总体趋势，并按年龄组进一步分类（= 55岁）。所有妇女的肥胖率都有所增加，但对45岁以下的妇女来说最显著，20至34岁妇女增加了16.3%，35至44岁妇女增加了17.9%。子宫内膜癌的发病率在所有年龄组中也有所增加，尽管45岁以下患者的发病率增加了14倍以上（从2000年至2005年）。
BACKGROUND: The prevalence of obesity has increased significantly in recent decades, particularly among younger women, and is a known risk factor for endometrial cancer.OBJECTIVE: This study aimed to evaluate the trend in the prevalence of obesity and the incidence of type I endometrial cancer over time in various age categories to determine whether an ecological relationship exists.STUDY DESIGN: Data from the Surveillance, Epidemiology, and End Results Program and the National Health and Nutrition Examination Survey were used. The overall trend in the incidence of type 1 endometrial cancer and prevalence of obesity were observed over time from 1988 to 2016 and further categorized by age group (= 55 years).RESULTS: The prevalence of obesity has increased for all women, but most significantly for women younger than 45 years with a 16.3% increase among women aged 20 to 34 years and a 17.9% increase for women aged 35 to 44 years. The incidence of endometrial cancer has also increased across all age categories, and although it has increased in patients younger than 45 years by more than 14-fold (from