Cell Culture on a Carbon Nanotube Scaffold
Cell Culture on a Carbon Nanotube Scaffold
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DOI：
10.1166/jbn.2005.048
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发表时间：
2005-12-01
影响因子：
2.9
通讯作者：
Watari, Furnio
中科院分区：
文献类型：
--
作者：
Aoki, Naofurni;Yokoyama, Atsuro;Watari, Furnio
纳米材料如碳纳米管（CNTs）在医学上的应用引起了广泛的关注。在本研究中，我们尝试开发碳纳米管作为细胞培养的支架。通过真空过滤在聚碳酸酯膜上形成CNT支架，并使用扫描电子显微镜研究细胞增殖和形态。在碳纳米管上的成骨细胞（骨形成细胞）表现出良好的增殖，细胞形态在各个方向上延伸。大量的丝状伪足从细胞内向碳纳米管纤维聚集体内部延伸，并与支架紧密结合。这些结果表明，碳纳米管可以用作支架具有良好的细胞粘附的亲和力。
The developments of nanoscale substance such as carbon nanotubes (CNTs) for medical applications have attracted a great deal of attention. In the present study, an attempt was made to development of CNTs as scaffolds for cell culture. CNT scaffolds were formed on polycarbonate membranes by vacuum filtration and cell proliferation and morphology were investigated using a scanning electron microscopy. Osteoblast cells (bone-forming cell) on CNTs showed excellent proliferation with extension of cell morphology in all directions. Numerous filopodia were extended from cells toward the inside of fibrous aggregates of CNTs and tightly bound to scaffolds. These results suggest that CNTs can be used as scaffolds with excellent affinity for cell adhesion.