Changes in the molecular structure of the brain in bipolar disorder: findings using human postmortem brain tissue.
Changes in the molecular structure of the brain in bipolar disorder: findings using human postmortem brain tissue.
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DOI：
10.3109/15622970209150613
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发表时间：
2002-07-01
期刊：
影响因子：
--
通讯作者：
Dean, Brian
中科院分区：
文献类型：
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作者：
Dean, Brian
人类死后大脑的研究开始提示双相情感障碍病理背后的机制。证据暗示异常的g蛋白，神经递质转换，神经递质受体和神经递质受体信号放大将被审查。此外，个别研究表明突触前蛋白，神经元引导蛋白，神经肽，神经元内离子稳态和环境因子反应蛋白在疾病病理中的作用也被提出。总之，这些研究证实了双相情感障碍的病理是复杂的，但对该疾病患者死后脑组织的分子结构的深入研究正在产生影响。
Human postmortem brain studies are beginning to suggest mechanisms that underlie the pathology of bipolar disorder. Evidence that implicates abnormalities in G-protein, neurotransmitter turnover, neurotransmitter receptors and neurotransmitter receptor signal amplification will be reviewed. In addition, individual studies that suggest roles for pre-synaptic proteins, neuronal guidance proteins, neuropeptides, intra-neuronal ion homeostasis and environmental factor reactive proteins in the pathology of the disorder are also presented. Together these studies confirm that the pathology of bipolar disorder is complex but is yielding to intense study of the molecular architecture of postmortem brain tissue from subjects with the illness.